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Literature summary for 1.1.1.85 extracted from

  • Parsons, S.J.; Burns, R.O.
    Purification and properties of beta-isopropylmalate dehydrogenase (1969), J. Biol. Chem., 244, 996-1003.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide 50 mM, slight inhibition Salmonella enterica subsp. enterica serovar Typhimurium
iodoacetate 50 mM, slight inhibition Salmonella enterica subsp. enterica serovar Typhimurium
K+ above 1 M, slight inhibition Salmonella enterica subsp. enterica serovar Typhimurium
N-ethylmaleimide
-
Salmonella enterica subsp. enterica serovar Typhimurium
NEM
-
Salmonella enterica subsp. enterica serovar Typhimurium
p-hydroxymercuribenzoate
-
Salmonella enterica subsp. enterica serovar Typhimurium
PCMB
-
Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
(2R,3S)-3-isopropylmalate pH 9.0 Salmonella enterica subsp. enterica serovar Typhimurium
0.1
-
NAD+ pH 9.0 Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
2 * 35000, sedimentation equilibrium centrifugation after treatment with mercaptoethanol and 6 M guanidine-HCl Salmonella enterica subsp. enterica serovar Typhimurium
70000
-
equilibrium sedimentation Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+ Salmonella enterica subsp. enterica serovar Typhimurium enzyme is involved in leucine biosynthesis 2-oxoisocaproate + NADH + H+ + CO2
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+
-
Salmonella enterica subsp. enterica serovar Typhimurium 2-oxoisocaproate + NADH + H+ + CO2
-
?
(2R,3S)-3-isopropylmalate + NAD+ enzyme is involved in leucine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium 2-oxoisocaproate + NADH + H+ + CO2
-
?
(2R,3S)-3-isopropylmalate + NAD+
-
Salmonella enterica subsp. enterica serovar Typhimurium (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
r
(2R,3S)-3-isopropylmalate + thionicotinamide NAD+
-
Salmonella enterica subsp. enterica serovar Typhimurium 2-oxoisohexanoate + thionicotinamideNADH + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 35000, sedimentation equilibrium centrifugation after treatment with mercaptoethanol and 6 M guanidine-HCl Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Salmonella enterica subsp. enterica serovar Typhimurium