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Literature summary for 1.1.1.8 extracted from

  • Ou, X.; Ji, C.; Han, X.; Zhao, X.; Li, X.; Mao, Y.; Wong, L.L.; Bartlam, M.; Rao, Z.
    Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1) (2006), J. Mol. Biol., 357, 858-869.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL-21 DE3 as a fusion protein with glutathione S-transferase Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor-diffusion method enzyme/NAD+ complex, enzyme/dihydroxyacetonephosphate complex, enzyme/NAD+/dihydroxyacetonephosphate complex Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P21695
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroxyacetone phosphate + NADH an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analysis Homo sapiens sn-glycerol 3-phosphate + NAD+
-
?

Synonyms

Synonyms Comment Organism
glycerol 3-phosphate dehydrogenase 1
-
Homo sapiens
GPD1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens