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Literature summary for 1.1.1.75 extracted from
- Microbial metabolism of amino ketones. Aminoacetone formation from 1-aminopropan-2-ol by a dehydrgenase in Escerichia coli (1966), Biochem. J., 99, 427-433.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D,L-2hydroxy-2-phenylethylamine | slight inhibition | Escherichia coli |  |
| D,L-3-hydroxybutyrate | slight inhibition | Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
1-aminopropan-2-ol | washed cell suspension | Escherichia coli | |
| 0.8 | - |
1-aminopropan-2-ol | cell free extracts | Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | slight inhibition | Escherichia coli | |
| Fe2+ | slightly activating | Escherichia coli | |
| K+ | required | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-1-aminopropan-2-ol + NAD+ | Escherichia coli | - |
aminoacetone + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.003 | - |
under optimum conditions | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D,L-1-aminopropan-2-ol + NAD+ | more active with L-enantiomer, activity with D-enantiomer might be due to D-aminopropanol specific enzyme | Escherichia coli | aminoacetone + NADH | - |
? | |
| L-1-aminopropan-2-ol + NAD+ | - |
Escherichia coli | aminoacetone + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | - |
washed cell suspension | Escherichia coli |
| 7 | - |
cell free extracts | Escherichia coli |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 8 | washed cell suspension, very low activity at 4.5, 50% activity at pH 8 | Escherichia coli |
| 6.5 | 9 | cell free extracts, 50% activity at both pH | Escherichia coli |
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Release 2023.1 (January 2023)
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