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Literature summary for 1.1.1.71 extracted from

  • Ma, C.W.; Zhang, L.; Dai, J.Y;, Xiu, Z.L.
    Characterization and cofactor binding mechanism of a novel NAD(P)H-dependent aldehyde reductase from Klebsiella pneumoniae DSM2026 (2013), J. Microbiol. Biotechnol., 23, 1699-1707.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae DSM2026
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q Sepharose column chromatography, and Superdex 200 gel filtration Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxypropionaldehyde + NADPH + H+ 100% activity Klebsiella pneumoniae propan-1,3-diol + NADP+
-
?
3-hydroxypropionaldehyde + NADPH + H+ 100% activity Klebsiella pneumoniae DSM2026 propan-1,3-diol + NADP+
-
?
acetaldehyde + NADPH + H+ 2.2% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae ethanol + NADP+
-
?
acetaldehyde + NADPH + H+ 2.2% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM2026 ethanol + NADP+
-
?
acetoin + NADPH + H+ 1.9% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae ?
-
?
acrolein + NADPH + H+ 41.8% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae prop-2-en-1-ol + NADP+
-
?
butyraldehyde + NADPH + H+ 118.4% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae butanol + NADP+
-
?
butyraldehyde + NADPH + H+ 118.4% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM2026 butanol + NADP+
-
?
additional information no activity with dihydroxyacetone, hydroxyacetone, and acetone Klebsiella pneumoniae ?
-
?
additional information no activity with dihydroxyacetone, hydroxyacetone, and acetone Klebsiella pneumoniae DSM2026 ?
-
?
propionaldehyde + NADPH + H+ 37.1% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae propanol + NADP+
-
?
propionaldehyde + NADPH + H+ 37.1% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM2026 propanol + NADP+
-
?

Synonyms

Synonyms Comment Organism
NAD(P)H-dependent aldehyde reductase
-
Klebsiella pneumoniae
YqhD
-
Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
NADH
-
Klebsiella pneumoniae
NADPH
-
Klebsiella pneumoniae