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Literature summary for 1.1.1.67 extracted from

  • Huang, X.; Chen, X.; He, Y.; Yu, X.; Li, S.; Gao, N.; Niu, L.; Mao, Y.; Wang, Y.; Wu, X.; Wu, W.; Wu, J.; Zhou, D.; Zhan, X.; Chen, C.
    Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicans (2017), PLoS Pathog., 13, e1006414 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Candida albicans
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Synonyms

Synonyms Comment Organism
NAD+-dependent mannitol dehydrogenase
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Candida albicans

General Information

General Information Comment Organism
malfunction dysfunction of the mitochondrial complex I decreases the level of NAD+, downregulates the NAD+-dependent mannitol dehydrogenase activity, and inhibits hyphal growth and biofilm formation in conditions when the carbon source is mannitol, but not fermentative sugars like glucose Candida albicans