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Literature summary for 1.1.1.66 extracted from

  • Mitz, M.A.; Heinrikson, R.L.
    Omega-hydroxy fatty acid dehydrogenase (1961), Biochim. Biophys. Acta, 46, 45-50.
    View publication on PubMed
Search for more literature for 1.1.1.66

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.066
-
 NAD+
-
 Sus scrofa
0.08
-
 11-Hydroxyundecanoate
-
 Sus scrofa
0.125
-
 10-Hydroxydecanoate
-
 Sus scrofa
40
-
 9-Hydroxynonanoate
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
cytoplasm
-
 Sus scrofa 5737
-
cytoplasm
-
 Oryctolagus cuniculus 5737
-
cytoplasm
-
 Ovis aries 5737
-
cytoplasm
-
 Equus caballus 5737
-

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Sus scrofa
-
kidney
-
 Sus scrofa
-
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Ovis aries
-
liver
-
 Equus caballus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 223, units defined as change in optical density at 340 nm of 0.001/min Sus scrofa

Storage Stability

Storage Stability Organism
4°C, crude extract stable for a week Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-hydroxydecanoate + NAD+
-
 Rattus norvegicus 10-oxodecanoate + NADH
-
 ?
10-hydroxydecanoate + NAD+
-
 Oryctolagus cuniculus 10-oxodecanoate + NADH
-
 ?
10-hydroxydecanoate + NAD+
-
 Ovis aries 10-oxodecanoate + NADH
-
 ?
10-hydroxydecanoate + NAD+
-
 Equus caballus 10-oxodecanoate + NADH
-
 ?
10-hydroxydecanoate + NAD+ best substrate Sus scrofa 10-oxodecanoate + NADH
-
 r
11-hydroxyundecanoate + NAD+
-
 Rattus norvegicus 11-oxoundecanoate + NADH
-
 ?
11-hydroxyundecanoate + NAD+
-
 Oryctolagus cuniculus 11-oxoundecanoate + NADH
-
 ?
11-hydroxyundecanoate + NAD+
-
 Ovis aries 11-oxoundecanoate + NADH
-
 ?
11-hydroxyundecanoate + NAD+
-
 Equus caballus 11-oxoundecanoate + NADH
-
 ?
11-hydroxyundecanoate + NAD+ oxidation at 89% the rate of 10-hydroxydecanoic acid Sus scrofa 11-oxoundecanoate + NADH
-
 ?
9-hydroxynonanoate + NAD+
-
 Rattus norvegicus 9-oxononanoate + NADH
-
 ?
9-hydroxynonanoate + NAD+
-
 Oryctolagus cuniculus 9-oxononanoate + NADH
-
 ?
9-hydroxynonanoate + NAD+
-
 Ovis aries 9-oxononanoate + NADH
-
 ?
9-hydroxynonanoate + NAD+
-
 Equus caballus 9-oxononanoate + NADH
-
 ?
9-hydroxynonanoate + NAD+ oxidation at 51% the rate of 10-hydroxydecanoic acid Sus scrofa 9-oxononanoate + NADH
-
 ?
additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Rattus norvegicus ?
-
 ?
additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Sus scrofa ?
-
 ?
additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Oryctolagus cuniculus ?
-
 ?
additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Ovis aries ?
-
 ?
additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Equus caballus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus
37
-
 assay at Sus scrofa
37
-
 assay at Oryctolagus cuniculus
37
-
 assay at Ovis aries
37
-
 assay at Equus caballus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
-
 Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
9 11 about half-maximal activity at pH 9.0 and 11.0 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+ cannot be replaced by NADP+ Rattus norvegicus
NAD+ cannot be replaced by NADP+ Sus scrofa
NAD+ cannot be replaced by NADP+ Oryctolagus cuniculus
NAD+ cannot be replaced by NADP+ Ovis aries
NAD+ cannot be replaced by NADP+ Equus caballus