Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3alpha,5alpha)-3-([(2R,5S)-2,5-dimethyl-4-[2-(trifluoromethyl)benzene-1-sulfonyl]piperazin-1-yl]methyl)-3-hydroxyandrostan-17-one | 48.8-92.0% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
(3R,5'R,10S,13S)-4',5'-dibenzyl-10,13-dimethyltetradecahydro-6'H-spiro[cyclopenta[a]phenanthrene-3,2'-[1,4]oxazinane]-6',17(2H)-dione | 6.2-19.5% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
(3R,5'R,10S,13S)-5'-benzyl-10,13-dimethyltetradecahydro-6'H-spiro[cyclopenta[a]phenanthrene-3,2'-[1,4]oxazinane]-6',17(2H)-dione | 58.2-90.4% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
(3R,5'S,10S,13S)-4',5'-dibenzyl-10,13-dimethyltetradecahydro-6'H-spiro[cyclopenta[a]phenanthrene-3,2'-[1,4]oxazinane]-6',17(2H)-dione | 25.6-87.3% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
(3R,5'S,10S,13S)-5'-benzyl-10,13-dimethyltetradecahydro-6'H-spiro[cyclopenta[a]phenanthrene-3,2'-[1,4]oxazinane]-6',17(2H)-dione | 18.5-63.2% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
(3S)-3,4-dibenzyl-1-oxa-4-azaspiro[5.5]undecan-2-one | 47.3-92.1% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
(3S)-3-benzyl-1-oxa-4-azaspiro[5.5]undecan-2-one | 24.2-24.3% inhibition at 0.0001-0.001 mM | Rattus norvegicus | |
additional information | synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADP+ | Rattus norvegicus | - |
androstenedione + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADP+ | - |
Rattus norvegicus | androstenedione + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD3 | - |
Rattus norvegicus |
17beta-hydroxysteroid dehydrogenase type 3 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000014 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3alpha,5alpha)-3-([(2R,5S)-2,5-dimethyl-4-[2-(trifluoromethyl)benzene-1-sulfonyl]piperazin-1-yl]methyl)-3-hydroxyandrostan-17-one | |
0.000022 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3R,5'S,10S,13S)-5'-benzyl-10,13-dimethyltetradecahydro-6'H-spiro[cyclopenta[a]phenanthrene-3,2'-[1,4]oxazinane]-6',17(2H)-dione | |
0.000048 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (3R,5'S,10S,13S)-4',5'-dibenzyl-10,13-dimethyltetradecahydro-6'H-spiro[cyclopenta[a]phenanthrene-3,2'-[1,4]oxazinane]-6',17(2H)-dione |