Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R,10S,13S)-3-(Adamantan-1-ylmethyl-butyl-amino)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | IC50: 80 nM | Homo sapiens | |
(3R,10S,13S)-3-[(2-Cyclopentyl-ethyl)-morpholin-4-yl-amino]-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | IC50: 74 nM | Homo sapiens | |
(RS)-3(2,3,3-triphenyl-prop-2-enoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione | IC50: 0.0091 mM, reduction of androstenedione | Homo sapiens | |
2,5-diphenyl-p-benzoquinone | IC50: 0.0027 mM, reduction of androstenedione | Homo sapiens | |
3-(4-Bromo-2-methyl-benzyl)-7-hydroxy-chroman-4-one | IC50: 0.0083 mM, reduction of androstenedione | Homo sapiens | |
3-(4-Chloro-2-methyl-benzyl)-7-hydroxy-chroman-4-one | IC50: 0.0018 mM, reduction of androstenedione | Homo sapiens | |
3-(4-Fluoro-2-methyl-benzyl)-7-hydroxy-chroman-4-one | IC50: 0.007 mM, reduction of androstenedione | Homo sapiens | |
3-cyclohexyl-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | - |
Homo sapiens | |
3-cyclohexylmethyl-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | - |
Homo sapiens | |
3-hexyl-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | - |
Homo sapiens | |
3-hydroxy-10,13-dimethyl-3-octyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | - |
Homo sapiens | |
3-hydroxy-10,13-dimethyl-3-phenethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | - |
Homo sapiens | |
3-hydroxy-10,13-dimethyl-3-phenyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | - |
Homo sapiens | |
3b-Methyl-5a-androstan-3a-ol-17-on | - |
Homo sapiens | |
3beta-cyclohexylethyl-androsterone | IC50: 60 nM | Homo sapiens | |
3beta-phenylmethyl-androsterone | IC50: 57 nM | Homo sapiens | |
3beta-propyl-androsterone | IC50: 67 nM | Homo sapiens | |
3beta-sec-butyl-androsterone | IC50: 73 nM | Homo sapiens | |
4-estrene-3,17-dione | - |
Canis lupus familiaris | |
4-Methylumbelliferone | IC50: 0.0009 mM, reduction of androstenedione | Homo sapiens | |
5-androstene-3,17-dione | - |
Canis lupus familiaris | |
7-hydroxyflavone | IC50: 0.009 mM, reduction of androstenedione | Homo sapiens | |
atamestane | - |
Homo sapiens | |
baicalein | IC50: 0.0093 mM, reduction of androstenedione | Homo sapiens | |
Biochanin A | IC50: 0.0108 mM, reduction of androstenedione | Homo sapiens | |
Cyclopropanecarboxylic acid ((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-octyl-amide | IC50: 57 nM | Homo sapiens | |
Cyclopropanecarboxylic acid cyclohexylmethyl-((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-amide | IC50: 85 nM | Homo sapiens | |
heptanoic acid (1-{1-[(3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-ylmethyl)-carbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethyl)-amide | IC50: 227 nM | Homo sapiens | |
N-Adamantan-1-ylmethyl-N-((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-butyramide | IC50: 35-57 nM | Homo sapiens | |
phenyl-p-benzoquinone | IC50: 0.0057 mM, reduction of androstenedione | Homo sapiens | |
S-petasin | - |
Rattus norvegicus | |
umbelliferone | IC50: 0.0014 mM, reduction of androstenedione | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
androstenedione | - |
Homo sapiens | |
0.001 | - |
androstenedione | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Canis lupus familiaris | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
testis | - |
Rattus norvegicus | - |
testis | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androstenedione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
? | |
androstenedione + NADPH + H+ | - |
Rattus norvegicus | testosterone + NADP+ | - |
? | |
androstenedione + NADPH + H+ | - |
Canis lupus familiaris | testosterone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 3 17beta-HSD | - |
Homo sapiens |
type 3 17beta-HSD | - |
Rattus norvegicus |
type 3 17beta-HSD | - |
Canis lupus familiaris |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Rattus norvegicus | |
NADP+ | - |
Canis lupus familiaris | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Canis lupus familiaris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0024 | - |
4-estrene-3,17-dione | - |
Canis lupus familiaris | |
0.0068 | - |
5-androstene-3,17-dione | - |
Canis lupus familiaris |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000035 | 0.000057 | IC50: 35-57 nM | Homo sapiens | N-Adamantan-1-ylmethyl-N-((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-butyramide | |
0.000057 | - |
IC50: 57 nM | Homo sapiens | 3beta-phenylmethyl-androsterone | |
0.000057 | - |
IC50: 57 nM | Homo sapiens | Cyclopropanecarboxylic acid ((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-octyl-amide | |
0.00006 | - |
IC50: 60 nM | Homo sapiens | 3beta-cyclohexylethyl-androsterone | |
0.000067 | - |
IC50: 67 nM | Homo sapiens | 3beta-propyl-androsterone | |
0.000073 | - |
IC50: 73 nM | Homo sapiens | 3beta-sec-butyl-androsterone | |
0.000074 | - |
IC50: 74 nM | Homo sapiens | (3R,10S,13S)-3-[(2-Cyclopentyl-ethyl)-morpholin-4-yl-amino]-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | |
0.00008 | - |
IC50: 80 nM | Homo sapiens | (3R,10S,13S)-3-(Adamantan-1-ylmethyl-butyl-amino)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one | |
0.000085 | - |
IC50: 85 nM | Homo sapiens | Cyclopropanecarboxylic acid cyclohexylmethyl-((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-amide | |
0.000227 | - |
IC50: 227 nM | Homo sapiens | heptanoic acid (1-{1-[(3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-ylmethyl)-carbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethyl)-amide | |
0.0009 | - |
IC50: 0.0009 mM, reduction of androstenedione | Homo sapiens | 4-Methylumbelliferone | |
0.0014 | - |
IC50: 0.0014 mM, reduction of androstenedione | Homo sapiens | umbelliferone | |
0.0018 | - |
IC50: 0.0018 mM, reduction of androstenedione | Homo sapiens | 3-(4-Chloro-2-methyl-benzyl)-7-hydroxy-chroman-4-one | |
0.0027 | - |
IC50: 0.0027 mM, reduction of androstenedione | Homo sapiens | 2,5-diphenyl-p-benzoquinone | |
0.0057 | - |
IC50: 0.0057 mM, reduction of androstenedione | Homo sapiens | phenyl-p-benzoquinone | |
0.007 | - |
IC50: 0.007 mM, reduction of androstenedione | Homo sapiens | 3-(4-Fluoro-2-methyl-benzyl)-7-hydroxy-chroman-4-one | |
0.0083 | - |
IC50: 0.0083 mM, reduction of androstenedione | Homo sapiens | 3-(4-Bromo-2-methyl-benzyl)-7-hydroxy-chroman-4-one | |
0.009 | - |
IC50: 0.009 mM, reduction of androstenedione | Homo sapiens | 7-hydroxyflavone | |
0.0091 | - |
IC50: 0.0091 mM, reduction of androstenedione | Homo sapiens | (RS)-3(2,3,3-triphenyl-prop-2-enoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione | |
0.0093 | - |
IC50: 0.0093 mM, reduction of androstenedione | Homo sapiens | baicalein | |
0.0108 | - |
IC50: 0.0108 mM, reduction of androstenedione | Homo sapiens | Biochanin A |