Literature summary for 1.1.1.62 extracted from

Sali, V.K.; Mani, S.; Meenaloshani, G.; Velmurugan Ilavarasi, A.; Vasanthi, H.R.
Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells (2020), Steroids, 159, 108638 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
cholest-4-ene-3,6-dione	cholest-4-ene-3,6-dione arrests the enzymatic conversion of estrone to 17-beta estradiol, by inhibiting AKR1C3 in intact MCF-7 cells. It can be used as a molecular scaffold for further development of l small-molecules with better specificity towards AKR1C3; the inhibitor occupies the binding region of AKR1C3 with almost similar orientation as indomethacin, thereby acting as an antagonistic agent for AKR1C3. It induces inhibition of AKR1C3 and cell death in MCF-7 cells. IT can be used as a molecular scaffold for development of novel small-molecules with better specificity towards AKR1C3	Homo sapiens
indomethacin	specific inhibitor for AKR1C3	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
estrone + NADPH + H+	Homo sapiens	-	17beta-estradiol + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42330	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
estrone + NADPH + H+	-	Homo sapiens	17beta-estradiol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
AKR1C3	-	Homo sapiens
type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase	-	Homo sapiens

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Release 2023.1 (January 2023)