Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42330 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD | - |
Homo sapiens |
AKR1C3 | - |
Homo sapiens |
type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | by acting as a 17-ketosteroid reductase, AKR1C3 produces potent androgens in peripheral tissues which activate the androgen receptor or act as substrates for aromatase. AKR1C3 is implicated in the production of androgens in castration-resistant prostate cancer and polycystic ovarian syndrome and is implicated in the production of aromatase substrates in breast cancer | Homo sapiens |