Literature summary for 1.1.1.62 extracted from

Li, T.; Stephen, P.; Zhu, D.W.; Shi, R.; Lin, S.X.
Crystal structures of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition (2019), FEBS J., 286, 2155-2166 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 insect cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging-drop vapour diffusion method at 27°C, binary and ternary crystal structures of the enzyme complexed with estrone and NADP+, crystals in this study belonged to the space group P212121 and contain a dimer per asymmetric unit	Homo sapiens
hanging-drop vapour diffusion method at 27°C, crystallization of the enzyme in complex with estrone and NADP+. His221 is the key residue responsible for the reorganization and stabilization of the reversely bound estrone, leading to the formation of a dead end complex, which exists widely in NADP(H)-preferred enzymes for the regulation of their enzymatic activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
estrone	substrate inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14061	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary	the enzyme is primarily expressed in the placenta and ovarian granulose cells	Homo sapiens	-
placenta	the enzyme is primarily expressed in the placenta and ovarian granulose cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
17beta-HSD1	-	Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme catalyses the last step in estrogen activation	Homo sapiens
physiological function	the enzyme is involved in estrogen-dependent diseases	Homo sapiens

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Release 2023.1 (January 2023)