Literature summary for 1.1.1.62 extracted from

Trottier, A.; Maltais, R.; Ayan, D.; Barbeau, X.; Roy, J.; Perreault, M.; Poulin, R.; Laguee, P.; Poirier, D.
Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 (2017), Biochem. Pharmacol., 144, 149-161 .

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Application

Application	Comment	Organism
drug development	the enzyme constitutes an interesting therapeutic target for estrogen-dependent diseases	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-[[(16beta,17beta)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methyl] benzamide	irreversible inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14061	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
estrone + NAD(P)H + H+	-	Homo sapiens	estradiol + NAD(P)+	-	?

Synonyms

Synonyms	Comment	Organism
17beta-HSD1	-	Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme is involved in the biosynthesis of estradiol	Homo sapiens

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Release 2023.1 (January 2023)