Literature summary for 1.1.1.62 extracted from

Husen, B.; Huhtinen, K.; Saloniemi, T.; Messinger, J.; Thole, H.H.; Poutanen, M.
Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts (2006), Endocrinology, 147, 5333-5339.

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Application

Application	Comment	Organism
medicine	estrogenic response for estrone is enhanced by the local action of HSD17B1 in vivo. Thus the enzyme is a potential target for pharmacological inhibition of estrogen activation. Targeted inhibition of HSD17B1 is a promising therapeutic approach to modulate estrogen response in the target tissue with less severe side effects as compared with antiestrogens	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
MCF-7 cells stable transfected with an expression plasmid for human HSD17B1	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
estrone + NAD(P)H + H+	Homo sapiens	the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions	estradiol + NAD(P)+	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
estrone + NAD(P)H + H+	the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions	Homo sapiens	estradiol + NAD(P)+	-	r

Synonyms

Synonyms	Comment	Organism
HSD17B1	-	Homo sapiens
hydroxysteroid (17-beta) dehydrogenase 1	-	Homo sapiens

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Release 2023.1 (January 2023)