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Literature summary for 1.1.1.62 extracted from

  • Steckelbroeck, S.; Watzka, M.; Reissinger, A.; Wegener-Toper, P.; Bidlingmaier, F.; Bliesener, N.; Hans, V.H.; Clusmann, H.; Ludwig, M.; Siekmann, L.; Klingmuller, D.
    Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain (2003), J. Steroid Biochem. Mol. Biol., 86, 79-92.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 NADPH
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
membrane isoforms 4 and 10 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estradiol-17beta + NAD+ Homo sapiens
-
 estrone + NADH
-
 ?
estrone + NADPH + H+ Homo sapiens final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain estradiol-17beta + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms 4, 5, 7, 8, 10, and 11, 17beta-HSD 4, 5, 7, 8, 10, and 11
-

Reaction

Reaction Comment Organism Reaction ID
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ isoforms differs in substrate specificity and tissue distribution, some enzyme forms displays also other activities such as type 4 that acts also as a short chain alcohol dehydrogenase and hydratase and type 10, that is identical to endoplasmic amyloid-beta-binding protein and mitochondrial short chain L-3-hydroxyacyl-CoA dehydrogenase Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
cardiac muscle low level Homo sapiens
-
liver high activity Homo sapiens
-
placenta isoform 8 is highly expressed, low level of isoform 5 Homo sapiens
-
prostate
-
 Homo sapiens
-
temporal lobe
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androst-4-ene-3,17-dione + NADPH
-
 Homo sapiens androst-4-ene-17beta-ol-3-one + NADP+
-
 ?
estradiol-17beta + NAD+
-
 Homo sapiens estrone + NADH
-
 ?
estrone + NADPH + H+
-
 Homo sapiens estradiol-17beta + NADP+
-
 ?
estrone + NADPH + H+ final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain Homo sapiens estradiol-17beta + NADP+
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 9 estrone reduction Homo sapiens
9
-
 estradiol-17beta oxidation Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 9.5 estrone reduction Homo sapiens
7.5 9.5 estradiol-17beta oxidation Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ oxidation Homo sapiens
NADPH reduction Homo sapiens