Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.62 extracted from

  • Ng, J.H.; Nesaretnam, K.; Reimann, K.; Lai, L.C.
    Effect of retinoic acid and palm oil carotenoids on oestrone sulphatase and oestradiol-17beta hydroxysteroid dehydrogenase activities in MCF-7 and MDA-MB-231 breast cancer cell lines (2000), Int. J. Cancer, 88, 135-138.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
palm oil carotenoids 0.001 mM, significant stimulation of the conversion of estradiol to estrone in the MCF-7 cell line Homo sapiens
retinoic acid 0.001 mM, significant stimulation of the conversion of estradiol to estrone in the MCF-7 cell line and MDA-MB-231 cell line, 0.0001 mM has no effect Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
palm oil carotenoids 0.0001 mM, significant inhibition of the conversion of estradiol to estrone in the MCF-7 cell line Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NADH Homo sapiens the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer estradiol-17beta + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD+
-
Homo sapiens estrone + NADH
-
?
estrone + NADH the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer Homo sapiens estradiol-17beta + NAD+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Homo sapiens