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Literature summary for 1.1.1.62 extracted from

  • Blomquist, C.H.; Leung, B.S.; Zhang, R.; Zhu, Y.; Chang, P.M.
    Properties and regulation of 17beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone (1995), J. Cell. Biochem., 59, 409-417.
    View publication on PubMed
Search for more literature for 1.1.1.62

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol type 1 enzyme Homo sapiens 5829
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microsome type 2 enzyme Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NADH Homo sapiens exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol estradiol-17beta + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
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 Homo sapiens
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A-431 cell epidermoid tumor of the vulva, A431 Homo sapiens
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breast cell line
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 Homo sapiens
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CAOV-3 cell enzyme type 2 from ovarian tumor: CAOV-3 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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ovarian cancer cell enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 and epidermoid tumor of the vulva, A431 Homo sapiens
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ovary enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 Homo sapiens
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OVCAR-3 cell enzyme type 2 from ovarian tumor: OVCAR-3 Homo sapiens
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T47D cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD+ type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens estrone + NADH
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 ?
estrone + NADH exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol Homo sapiens estradiol-17beta + NAD+
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 ?
estrone + NADPH + H+ type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens estradiol-17beta + NADP+
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 ?
additional information type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 enzyme is a membrane bound isoform reactive with both estradiol and testosterone Homo sapiens ?
-
 ?
testosterone + NADP+
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 Homo sapiens 4-androstene-3,17-dione + NADPH + H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Homo sapiens