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Literature summary for 1.1.1.51 extracted from

  • Hilborn, E.; Stal, O.; Alexeyenko, A.; Jansson, A.
    The regulation of hydroxysteroid 17beta-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer (2017), Oncotarget, 8, 62183-62194 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.51

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
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-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell line
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
HSD17B1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens estradiol negatively regulates HSD17B1 in breast cancer cell lines. Dihydrotestosterone has a primarily reductive impact on HSD17B1 expression down
Homo sapiens GREB1 downregulation suppresses HSD17B1 down
Homo sapiens miRNA-1304-3p reduces HSD17B1 expression down
Homo sapiens miRNA-210 and miRNA-7-5p have up- and down-regulatory effect down
Homo sapiens downregulation of CX3CL1, EPHB6, and TP63 increases HSD17B1 and HSD17B2 expression up
Homo sapiens miRNA-17 upregulates HSD17B1 up
Homo sapiens miRNA-210 and miRNA-7-5p have up- and down-regulatory effect up

General Information

General Information Comment Organism
metabolism HSD17B1 is controlled by estradiol, dihydrotestosterone, and miRNAs, as well as modulated by several breast cancer related genes Homo sapiens