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Literature summary for 1.1.1.51 extracted from
- Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid (2010), J. Steroid Biochem. Mol. Biol., 118, 13-17.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Perfluorooctanoic acid | - |
Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00067 | - |
pregnenolone | pH and temperature not specified in the publication | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-androsten-3,17-dione + NADPH + H+ | - |
Rattus norvegicus | testosterone + NADP+ | - |
? | |
| pregnenolone + NADP+ | - |
Rattus norvegicus | progesterone + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
| 3beta-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0153 | - |
Perfluorooctanoic acid | testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | |
| 0.0213 | - |
Perfluorooctanoic acid | testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | |
| 0.0586 | - |
Perfluorooctanoic acid | intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | |
| 0.181 | - |
Perfluorooctanoic acid | intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0177 | - |
testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | Perfluorooctanoic acid | |
| 0.0532 | - |
testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | Perfluorooctanoic acid | |
| 0.146 | - |
intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | Perfluorooctanoic acid | |
| 0.194 | - |
intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | Perfluorooctanoic acid | |
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