Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Perfluorooctanoic acid | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00067 | - |
pregnenolone | pH and temperature not specified in the publication | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androsten-3,17-dione + NADPH + H+ | - |
Rattus norvegicus | testosterone + NADP+ | - |
? | |
pregnenolone + NADP+ | - |
Rattus norvegicus | progesterone + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
3beta-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0153 | - |
Perfluorooctanoic acid | testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | |
0.0213 | - |
Perfluorooctanoic acid | testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | |
0.0586 | - |
Perfluorooctanoic acid | intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | |
0.181 | - |
Perfluorooctanoic acid | intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0177 | - |
testicular microsome, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | Perfluorooctanoic acid | |
0.0532 | - |
testicular microsome, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | Perfluorooctanoic acid | |
0.146 | - |
intact Leydig cells, pH and temperature not specified in the publication, inhibition of 3beta-hydroxysteroid dehydrogenase | Rattus norvegicus | Perfluorooctanoic acid | |
0.194 | - |
intact Leydig cells, inhibition of 17beta-hydroxysteroid dehydrogenase, pH and temperature not specified in the publication | Rattus norvegicus | Perfluorooctanoic acid |