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Literature summary for 1.1.1.51 extracted from
- Reductase activity of 17beta-hydroxysteroid oxidoreductase in prostatic tumors of different histological structure (2005), Bull. Exp. Biol. Med., 139, 715-717.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| androst-4-ene-3,17-dione + NADPH | Homo sapiens | - |
testosterone + NADP+ | - |
? |  |
| androstane-3,17-dione + NADPH | Homo sapiens | - |
dihydrotestosterone + NADP+ | - |
? | |
| additional information | Homo sapiens | activity of the enzyme is associated with the mechanism of prostatic regulation by androgens after castration, which is important in prostate cancer | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate cancer cell | cancer and bening hyperplasia, protstaic intraepithelial neoplasia, enzyme distribution, overview | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
determination of serum and tumor tissue concentrations of steroids in prostate cancer patients, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| androst-4-ene-3,17-dione + NADPH | - |
Homo sapiens | testosterone + NADP+ | - |
? | |
| androstane-3,17-dione + NADPH | - |
Homo sapiens | dihydrotestosterone + NADP+ | - |
? | |
| additional information | activity of the enzyme is associated with the mechanism of prostatic regulation by androgens after castration, which is important in prostate cancer | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-HSOR | - |
Homo sapiens |
| 17beta-hydroxysteroid oxidoreductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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