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Literature summary for 1.1.1.50 extracted from

  • Stolz, A.; Takikawa, H.; Sugiyama, Y.; Kuhlenkamp, J.; Kaplowitz, N.
    3alpha-hydroxysteroid dehydrogenase activity of the Y'bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance (1987), J. Clin. Invest., 79, 427-434.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.50

Inhibitors

Inhibitors Comment Organism Structure
cholic acid complete inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus belongs to the group of Y'bile acid binders, bile acid metabolizing enzymes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
three forms I, II, III Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-oxocholic acid + NADPH reverse reaction rate negligible Rattus norvegicus 3alpha-hydroxycholic acid + NADP+
-
 ir
additional information belongs to the group of Y'bile acid binders, bile acid metabolizing enzymes Rattus norvegicus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 alpha-HSD I Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH preference for Rattus norvegicus