Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Methylpyrrole acetic acid | - |
Rattus norvegicus | |
acetaminophen | - |
Rattus norvegicus | |
arylpropionic acid | - |
Rattus norvegicus | |
Fenamates | - |
Rattus norvegicus | |
indomethacin | - |
Rattus norvegicus | |
Medroxyprogesterone acetate | - |
Rattus norvegicus | |
Norethindrone | - |
Rattus norvegicus | |
progesterone | - |
Rattus norvegicus | |
Salicylates | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | 0.0083 | 5alpha-dihydrotestosterone | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31000 | - |
1 * 31000, SDS-PAGE | Rattus norvegicus |
32500 | 34000 | gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NAD(P)H + H+ | Rattus norvegicus | - |
5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.2 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-80°C, 20 mM potassium phosphate buffer, pH 7.0, 0.1 M EDTA, 1 mM mercaptoethanol, 20% glycerol, 3 months, 10-15% loss of activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NAD(P)H + H+ | i.e. 5alpha-androstan-17beta-ol-3-one | Rattus norvegicus | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | i.e. 5alpha-androstan-17beta-ol-3-one | Rattus norvegicus | (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Rattus norvegicus | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 31000, SDS-PAGE | Rattus norvegicus |