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Literature summary for 1.1.1.50 extracted from

  • Penning, T.M.; Sharp, R.B.; Krieger, N.R.
    Purification and properties of 3alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins (1985), J. Biol. Chem., 260, 15266-15272.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-Methylpyrrole acetic acid
-
Rattus norvegicus
acetaminophen
-
Rattus norvegicus
arylpropionic acid
-
Rattus norvegicus
Fenamates
-
Rattus norvegicus
indomethacin
-
Rattus norvegicus
Medroxyprogesterone acetate
-
Rattus norvegicus
Norethindrone
-
Rattus norvegicus
progesterone
-
Rattus norvegicus
Salicylates
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007 0.0083 5alpha-dihydrotestosterone
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
1 * 31000, SDS-PAGE Rattus norvegicus
32500 34000 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NAD(P)H + H+ Rattus norvegicus
-
5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.2
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-80°C, 20 mM potassium phosphate buffer, pH 7.0, 0.1 M EDTA, 1 mM mercaptoethanol, 20% glycerol, 3 months, 10-15% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NAD(P)H + H+ i.e. 5alpha-androstan-17beta-ol-3-one Rattus norvegicus 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
r
5alpha-dihydrotestosterone + NAD(P)H + H+ i.e. 5alpha-androstan-17beta-ol-3-one Rattus norvegicus (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+
-
r
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Rattus norvegicus 5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 31000, SDS-PAGE Rattus norvegicus