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Literature summary for 1.1.1.49 extracted from

  • Ozer, N.; Aksoy, Y.; Ogus, I.H.
    Kinetic properties of human placental glucose-6-phosphate dehydrogenase (2001), Int. J. Biochem. Cell Biol., 33, 221-226.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-diphosphoglycerate
-
Homo sapiens
NADP+ at concentrations above 0.3 mM Homo sapiens
NADPH NADPH binding is important for physiological regulation of pentose phosphate pathway Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
NADP+ with D-glucose 6-phosphate or D-galactose 6-phosphate Homo sapiens
0.03
-
NADP+ with 2-deoxyglucose 6-phosphate, KM decreases to 10 mM with increasing substrate concentration from 0.3 to 1.5 mM Homo sapiens
0.04
-
D-glucose 6-phosphate
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O + NADP+ Homo sapiens hyperbolic cofactor binding D-gluconate 6-phosphate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+ rapid equilibrium ordered bi bi kinetic Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
-10°C, 10 mM Tris-HCl, pH 7.4, 5 mM 2-mercaptoethanol, 2 mM EDTA, 40% glycerol (v/v), weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-D-glucose-6-phosphate + NADP+
-
Homo sapiens 2-deoxy-D-gluconate 6-phosphate + NADPH
-
?
D-galactose 6-phosphate + NAD(P)+
-
Homo sapiens D-galactonate 6-phosphate + NADH
-
?
D-glucose 6-phosphate + deamino-NADP+
-
Homo sapiens ?
-
?
D-glucose 6-phosphate + H2O + NADP+ hyperbolic cofactor binding Homo sapiens D-gluconate 6-phosphate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer
-
Homo sapiens
More presence of SH-reagents, high enzyme and Mg2+ or Mn2+ concentrations, low pH and ionic strength favour oligomeric, active forms of the enzyme, while the opposite conditions favour inactive monomers Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
43
-
2-deoxyglucose 6-phosphate
-
Homo sapiens
98
-
deamino-NADP+
-
Homo sapiens
157
-
D-galactose 6-phosphate
-
Homo sapiens
571
-
D-glucose 6-phosphate
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
deamino-NADP+
-
Homo sapiens
NADP+ high preference for Homo sapiens