Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1-(1-(4-chlorophenyl)-2-nitroethyl)-1H-indole | - |
Rattus norvegicus | |
1-(1-(furan-2-yl)-2-nitroethyl)-1H-indole | - |
Rattus norvegicus | |
1-(2-nitro-1-phenylethyl)-1H-indole | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1H-indol-1-yl)(furan-2-yl)methanon | noncompetitive | Rattus norvegicus | |
(1H-indol-1-yl)(furan-2-yl)methanone | noncompetitive inhibitor | Rattus norvegicus | |
(1H-indol-1-yl)(tiyophen-2-yl)methanon | competitive | Rattus norvegicus | |
(1H-indol-1-yl)(tiyophen-2-yl)methanone | competitive inhibitor | Rattus norvegicus | |
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole | competitive; competitive inhibitor | Rattus norvegicus | |
N-(4-chlorobenzoyl) indole | competitive | Rattus norvegicus | |
N-(4-chlorobenzoyl)-indole | competitive inhibitor | Rattus norvegicus | |
N-benzoylindole | noncompetitive; noncompetitive inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | Rattus norvegicus | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P85968 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Rattus norvegicus |
6PGD | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.483 | - |
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole | pH 8.0, 25°C | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00219 | - |
pH 8, 25°C | Rattus norvegicus | N-(4-chlorobenzoyl)-indole | |
0.00275 | - |
pH 8, 25°C | Rattus norvegicus | N-benzoylindole | |
0.00336 | - |
pH 8, 25°C | Rattus norvegicus | (1H-indol-1-yl)(tiyophen-2-yl)methanone | |
0.349 | - |
pH 8, 25°C | Rattus norvegicus | (1H-indol-1-yl)(furan-2-yl)methanone | |
0.99 | - |
pH 8, 25°C | Rattus norvegicus | 1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important function in various biochemical processes as it generates reducing power ofthe cell | Rattus norvegicus |