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Literature summary for 1.1.1.44 extracted from

  • Bayindir, S.; Temel, Y.; Ayna, A.; Ciftci, M.
    The synthesis of N-benzoylindoles as inhibitors of rat erythrocyte glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase (2018), J. Biochem. Mol. Toxicol., 32, e22193 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1-(1-(4-chlorophenyl)-2-nitroethyl)-1H-indole
-
Rattus norvegicus
1-(1-(furan-2-yl)-2-nitroethyl)-1H-indole
-
Rattus norvegicus
1-(2-nitro-1-phenylethyl)-1H-indole
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(1H-indol-1-yl)(furan-2-yl)methanon noncompetitive Rattus norvegicus
(1H-indol-1-yl)(furan-2-yl)methanone noncompetitive inhibitor Rattus norvegicus
(1H-indol-1-yl)(tiyophen-2-yl)methanon competitive Rattus norvegicus
(1H-indol-1-yl)(tiyophen-2-yl)methanone competitive inhibitor Rattus norvegicus
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole competitive; competitive inhibitor Rattus norvegicus
N-(4-chlorobenzoyl) indole competitive Rattus norvegicus
N-(4-chlorobenzoyl)-indole competitive inhibitor Rattus norvegicus
N-benzoylindole noncompetitive; noncompetitive inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Rattus norvegicus
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P85968
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
Rattus norvegicus
6PGD
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.483
-
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole pH 8.0, 25°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00219
-
pH 8, 25°C Rattus norvegicus N-(4-chlorobenzoyl)-indole
0.00275
-
pH 8, 25°C Rattus norvegicus N-benzoylindole
0.00336
-
pH 8, 25°C Rattus norvegicus (1H-indol-1-yl)(tiyophen-2-yl)methanone
0.349
-
pH 8, 25°C Rattus norvegicus (1H-indol-1-yl)(furan-2-yl)methanone
0.99
-
pH 8, 25°C Rattus norvegicus 1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole

General Information

General Information Comment Organism
physiological function the enzyme plays an important function in various biochemical processes as it generates reducing power ofthe cell Rattus norvegicus