Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.44 extracted from

  • Li, H.; Ericsson, M.; Rabasha, B.; Budnik, B.; Chan, S.H.; Freinkman, E.; Lewis, C.A.; Doench, J.G.; Wagner, B.K.; Garraway, L.A.; Schreiber, S.L.
    6-Phosphogluconate dehydrogenase links cytosolic carbohydrate metabolism to protein secretion via modulation of glutathione levels (2019), Cell Chem. Biol., 26, 1306-1314 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.44

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52209
-
-

Source Tissue

Source Tissue Comment Organism Textmining
UACC-257 cell
-
 Homo sapiens
-
WM-793B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
 Homo sapiens
Pgd
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme suppression causes a characteristic ER-dilation phenotype that is associated with increased extracellular matrix protein inside cells as well as decreased secretion Homo sapiens
metabolism 6-phosphogluconate dehydrogenase links cytosolic carbohydrate metabolism to protein secretion via modulation of glutathione levels Homo sapiens
physiological function the enzyme involved in carbohydrate metabolism, is required for endoplasmic reticulum structural integrity and protein secretion Homo sapiens