Protein Variants | Comment | Organism |
---|---|---|
M13C | mutant showing decrease in affinity for NADP+, but not NADPH | Ovis aries |
M13F | mutant showing decrease in affinity for NADP+, but not NADPH | Ovis aries |
M13I | mutant showing decrease in affinity for NADP+, but not NADPH | Ovis aries |
M13Q | mutant showing decrease in affinity for NADP+, but not NADPH | Ovis aries |
M13V | mutant showing decrease in affinity for NADP+, but not NADPH | Ovis aries |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADPH | competitive inhibition versus NADP+ with 6-phospho-D-gluconate equal to its Km and at a saturating concentration | Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
NADP+ | wild type enzyme | Ovis aries | |
0.0064 | - |
NADP+ | mutant enzyme M13C | Ovis aries | |
0.019 | - |
NADP+ | mutant enzyme M13F | Ovis aries | |
0.019 | - |
NADP+ | mutant enzyme M13Q | Ovis aries | |
0.026 | - |
NADP+ | mutant enzyme M13V | Ovis aries | |
0.032 | - |
NADP+ | mutant enzyme M13I | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | P00349 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA resin column chromatography and 2?5?ADP agarose chromatography | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Ovis aries |
6PGDH | - |
Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Ovis aries |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00065 | - |
NADPH | mutant enzyme M13C, at a saturating concentration | Ovis aries | |
0.001 | - |
NADPH | mutant enzyme M13I, at a saturating concentration | Ovis aries | |
0.0011 | - |
NADPH | wild type enzyme, at a saturating concentration | Ovis aries | |
0.0015 | - |
NADPH | mutant enzyme M13F, at a saturating concentration | Ovis aries | |
0.0021 | - |
NADPH | mutant enzyme M13Q, at a saturating concentration | Ovis aries | |
0.006 | - |
NADPH | mutant enzyme M13V, at a saturating concentration | Ovis aries |