Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine 5'-triphosphate | ATP inhibits the enzyme which is active with NAD+, not the NADP+ dependent activity | Burkholderia cepacia | |
ATP | NAD+-specific enzyme | Enterococcus faecalis | |
fructose 1,6-bisphosphate | NADP+-specific enzyme | Enterococcus faecalis | |
guanosine 5'-triphosphate | GTP inhibits the NADP+ specific enzyme | Burkholderia cepacia | |
NADPH | inhibition is competitive with respect to NADP+ | Burkholderia cepacia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
6-phospho-D-gluconate | - |
Burkholderia cepacia | |
0.02 | - |
NADP+ | enzyme active with NAD+ and NADP+-specific enzyme | Burkholderia cepacia | |
0.2 | - |
NAD+ | - |
Burkholderia cepacia | |
0.2 | - |
6-phospho-D-gluconate | - |
Burkholderia cepacia | |
0.3 | - |
6-phospho-D-gluconate | enzyme active with NAD+ or NADP+ | Burkholderia cepacia | |
0.7 | - |
6-phospho-D-gluconate | - |
Burkholderia cepacia | |
1 | - |
6-phospho-D-gluconate | 0.005 M GTP | Burkholderia cepacia |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
2 * 40000, enzyme active with NAD+ | Burkholderia cepacia |
57000 | - |
2 * 57000 | Neurospora crassa |
60000 | - |
2 * 60000, enzyme specific for NADP+ | Burkholderia cepacia |
82000 | - |
enzyme active with NAD+, sucrose density gradient sedimentation | Burkholderia cepacia |
84000 | - |
enzyme active with NAD+, gel filtration | Burkholderia cepacia |
110000 | 120000 | NADP+-specific enzyme | Neurospora crassa |
120000 | - |
NADP+-specific enzyme, gel filtration | Burkholderia cepacia |
123000 | - |
NADP+-specific enzyme, sucrose density gradient sedimentation | Burkholderia cepacia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NAD(P)+ | Neurospora crassa | - |
6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
6-phospho-D-gluconate + NAD(P)+ | Pseudomonas aeruginosa | - |
6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
6-phospho-D-gluconate + NAD(P)+ | Enterococcus faecalis | - |
6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
6-phospho-D-gluconate + NAD(P)+ | Burkholderia cepacia | - |
6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Burkholderia cepacia | - |
ATCC 17616, synonymous with Pseudomonas cepacia | - |
Enterococcus faecalis | - |
- |
- |
Neurospora crassa | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Burkholderia cepacia |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
34 | - |
NADP+ as cofactor | Burkholderia cepacia |
42.3 | - |
NAD+ as cofactor | Burkholderia cepacia |
Storage Stability | Organism |
---|---|
0°C both 6-phosphogluconate dehydrogenase species obtained by treatment with ammonium sulfate retain 100% of their activity when stored for several months | Burkholderia cepacia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NAD(P)+ | - |
Neurospora crassa | 6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
6-phospho-D-gluconate + NAD(P)+ | - |
Pseudomonas aeruginosa | 6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
6-phospho-D-gluconate + NAD(P)+ | - |
Enterococcus faecalis | 6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
6-phospho-D-gluconate + NAD(P)+ | - |
Burkholderia cepacia | 6-phospho-2-dehydro-D-gluconate + NAD(P)H | - |
r | |
D-glucose-6-phosphate + NAD+ | enzyme active with NAD+, 2% of the activity compared to 6-phosphogluconate when NAD+ is cofactor, no activity detected with NADP+ as cofactor | Burkholderia cepacia | 2-dehydro-6-phospho-D-glucose + NADH | - |
? | |
D-glucose-6-phosphate + NADP+ | NADP-specific enzyme, 4% of the activity with 6-phosphogluconate | Burkholderia cepacia | 2-dehydro-6-phospho-D-glucose + NADPH | - |
? | |
additional information | appears to lack 6PGAD except during growth on glucose or gluconate | Pseudomonas aeruginosa | ? | - |
? | |
additional information | glucose, 2-deoxyglucose, gluconate, fructose-6-phosphate, glucose-1-phosphate, fructose-1,6-diphosphate, ribulose-5-phosphate and 1,3-diphosphoglycerate are no substrates | Burkholderia cepacia | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 40000, enzyme active with NAD+ | Burkholderia cepacia |
dimer | 2 * 60000, enzyme specific for NADP+ | Burkholderia cepacia |
dimer | 2 * 57000 | Neurospora crassa |
Synonyms | Comment | Organism |
---|---|---|
6PGAD | - |
Pseudomonas aeruginosa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
NADP-specific enzyme | Burkholderia cepacia |
8.5 | 9.5 | enzyme active with NAD+ | Burkholderia cepacia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Burkholderia cepacia |