Crystallization (Comment) | Organism |
---|---|
enzyme in complex with phenylpyruvate is crystallized by hanging drop vapor diffusion against a reservoir solution containing 200 mM CaCl2, 100 mM HEPES pH 7.5, and 2.5 mM NAD+. Enzyme in complex with 2-hydroxyimino-3-phenylpropanoic acid is crystallized by vapor diffusion against a reservoir solution containing 75 mM CaCl2, 100 mM HEPES pH 7.5, and 1 mM NADH | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(hydroxyimino)-3-phenylpropanoic acid | - |
Homo sapiens | |
phenylpyruvate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ | Homo sapiens | - |
(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ | - |
Homo sapiens | (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C-terminal-binding protein 1 | - |
Homo sapiens |
CTBP1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000745 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(hydroxyimino)-3-phenylpropanoic acid | |
0.135 | - |
pH and temperature not specified in the publication | Homo sapiens | phenylpyruvate |