Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.42 extracted from

  • Kong, M.J.; Han, S.J.; Kim, J.I.; Park, J.W.; Park, K.M.
    Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells (2018), Cell Death Dis., 9, 488 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.42

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Mus musculus
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P54071
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
renal tubule
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
 Mus musculus 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
IDH2
-
 Mus musculus
NADP+-dependent isocitrate dehydrogenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency increases cisplatin-induced oxidative damage in kidney tubule cells, inducing more severe nephrotoxicity Mus musculus
physiological function the enzyme is critical in the NADPH-associated mitochondrial antioxidant system and is involved in cisplatin nephrotoxicity. The mitochondrial enzyme-NADPH-glutathione antioxidant system is a target for the prevention of cisplatin-induced kidney cell death Mus musculus