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Literature summary for 1.1.1.42 extracted from

  • Kil, I.S.; Chung, K.H.; Park, J.W.
    Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances selenite-induced apoptosis (2010), Free Radic. Res., 44, 332-339.
    View publication on PubMed
Search for more literature for 1.1.1.42

Inhibitors

Inhibitors Comment Organism Structure
Selenite inactivates IDPm Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion IDPm Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
IDPm
-
 Homo sapiens
mitochondrial NADP+-dependent isocitrate dehydrogenase
-
 Homo sapiens
NADP+-dependent isocitrate dehydrogenase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens transfection of HeLa cells with siRNA leading to decreased activity of IDPm and enhanced susceptibility of the cells to selenite-induced apoptosis, overview additional information

General Information

General Information Comment Organism
physiological function the mitochondrial NADP+-dependent isocitrate dehydrogenase controls the mitochondrial redox balance by supplying NADPH for antioxidant systems Homo sapiens