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Literature summary for 1.1.1.42 extracted from

  • Yang, J.H.; Yang, E.S.; Park, J.W.
    Inactivation of NADP+-dependent isocitrate dehydrogenase by lipid peroxidation products (2004), Free Radic. Res., 38, 241-249.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxynonenal 50% inhibition at 37°C, after 1 h at 0.5 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation Homo sapiens
lipid hydroperoxide 50% inhibition at 37°C, after 1 h at 0.05 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation Homo sapiens
malondialdehyde 50% inhibition at 37°C, after 1 h at 5 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + CO2 + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
ICDH
-
Homo sapiens
NADP+-dependent isocitrate dehydrogenase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens