General Stability | Organism |
---|---|
instable in solutions of low ionic strength, stabilization by ammonium sulfate | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ag+ | decarboxylation of isocitrate and oxalosuccinate | Sus scrofa | |
Cu2+ | - |
Sus scrofa | |
Diphenylchloroarsine | - |
Sus scrofa | |
isocitrate | competitive inhibition of decarboxylation of oxalosuccinate | Sus scrofa | |
p-chloromercuribenzoate | - |
Sus scrofa | |
p-hydroxymercuribenzoate | decarboxylation of isocitrate and oxalosuccinate | Sus scrofa | |
Phenarsazines | - |
Sus scrofa | |
Phenylmercuric nitrate | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0026 | - |
D,L-isocitrate | - |
Sus scrofa | |
0.0092 | - |
NADPH | - |
Sus scrofa | |
0.13 | - |
2-oxoglutarate | - |
Sus scrofa | |
0.56 | - |
oxalosuccinate | reductase | Sus scrofa | |
1.2 | - |
oxalosuccinate | decarboxylase | Sus scrofa | |
25 | 26 | oxalosuccinate | decarboxylase | Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | absolute requirement for divalent cations | Sus scrofa | |
Mg2+ | absolute requirement for divalent cations | Aspergillus niger | |
Mn2+ | absolute requirement for divalent cations | Sus scrofa | |
Mn2+ | absolute requirement for divalent cations | Aspergillus niger |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
61000 | 64000 | ultracentrifugation | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | Sus scrofa | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
r | |
isocitrate + NADP+ | Saccharomyces cerevisiae | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | Aspergillus niger | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | Mycobacterium tuberculosis | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | Trypanosoma cruzi | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | Citrobacter freundii | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus niger | - |
- |
- |
Citrobacter freundii | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Sus scrofa | - |
pig | - |
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NADP+ | - |
Sus scrofa | 2-oxoglutarate + NADPH + H+ + CO2 | - |
r | |
isocitrate + NADP+ | - |
Saccharomyces cerevisiae | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | - |
Aspergillus niger | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | - |
Mycobacterium tuberculosis | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | - |
Trypanosoma cruzi | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
isocitrate + NADP+ | - |
Citrobacter freundii | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
oxalosuccinate | - |
Sus scrofa | 2-oxoglutarate + CO2 | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
58.3 | - |
isocitrate | oxidative decarboxylation | Sus scrofa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.6 | 8.5 | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | natural coenzyme | Sus scrofa | |
NADP+ | natural coenzyme | Saccharomyces cerevisiae | |
NADP+ | natural coenzyme | Aspergillus niger | |
NADP+ | natural coenzyme | Mycobacterium tuberculosis | |
NADP+ | natural coenzyme | Trypanosoma cruzi | |
NADP+ | natural coenzyme | Citrobacter freundii | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Saccharomyces cerevisiae | |
NADPH | - |
Aspergillus niger | |
NADPH | - |
Mycobacterium tuberculosis | |
NADPH | - |
Trypanosoma cruzi | |
NADPH | - |
Citrobacter freundii |