Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.41 extracted from

  • Yang, C.; Fan, J.; Zhuang, Z.; Fang, Y.; Zhang, Y.; Wang, S.
    The role of NAD+-dependent isocitrate dehydrogenase 3 subunit alpha in AFB1 induced liver lesion (2014), Toxicol. Lett., 224, 371-379.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
IDH3alpha, DNA and amino acid sequence analysis and comparison Mus musculus
IDH3alpha, DNA and amino acid sequence analysis and comparison Rattus norvegicus
IDH3alpha, DNA and amino acid sequence analysis and comparison Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme overexpression, or enzyme downregulation by siRNA Mus musculus
additional information enzyme overexpression, or enzyme downregulation by siRNA Rattus norvegicus
additional information enzyme overexpression, or enzyme downregulation by siRNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Mus musculus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Rattus norvegicus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Homo sapiens
-
2-oxoglutarate + CO2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50213
-
-
Mus musculus Q9D6R2
-
-
Rattus norvegicus Q99NA5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
Homo sapiens
-
BEL-7404 cell
-
Homo sapiens
-
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
brain
-
Homo sapiens
-
Chang liver cell
-
Homo sapiens
-
heart
-
Mus musculus
-
heart
-
Rattus norvegicus
-
heart
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
kidney
-
Mus musculus
-
kidney
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
lung
-
Mus musculus
-
lung
-
Rattus norvegicus
-
lung
-
Homo sapiens
-
additional information ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit Mus musculus
-
additional information ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit Rattus norvegicus
-
additional information ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit Homo sapiens
-
skeletal muscle
-
Mus musculus
-
skeletal muscle
-
Rattus norvegicus
-
skeletal muscle
-
Homo sapiens
-
small intestine
-
Mus musculus
-
small intestine
-
Rattus norvegicus
-
small intestine
-
Homo sapiens
-
spleen
-
Mus musculus
-
spleen
-
Rattus norvegicus
-
spleen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Mus musculus 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Rattus norvegicus 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Homo sapiens 2-oxoglutarate + CO2 + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
IDH3alpha
-
Mus musculus
IDH3alpha
-
Rattus norvegicus
IDH3alpha
-
Homo sapiens
isocitrate dehydrogenase 3alpha subunit
-
Mus musculus
isocitrate dehydrogenase 3alpha subunit
-
Rattus norvegicus
isocitrate dehydrogenase 3alpha subunit
-
Homo sapiens
NAD+-dependent isocitrate dehydrogenase 3
-
Mus musculus
NAD+-dependent isocitrate dehydrogenase 3
-
Rattus norvegicus
NAD+-dependent isocitrate dehydrogenase 3
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NAD+
-
Rattus norvegicus
NAD+
-
Homo sapiens

Expression

Organism Comment Expression
Mus musculus aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion up
Rattus norvegicus aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion up
Homo sapiens aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion up

General Information

General Information Comment Organism
malfunction overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Akt pathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1 Mus musculus
malfunction overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1 Rattus norvegicus
malfunction overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1 Homo sapiens
physiological function IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B) Mus musculus
physiological function IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B) Rattus norvegicus
physiological function IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B) Homo sapiens