Cloned (Comment) | Organism |
---|---|
IDH3alpha, DNA and amino acid sequence analysis and comparison | Mus musculus |
IDH3alpha, DNA and amino acid sequence analysis and comparison | Rattus norvegicus |
IDH3alpha, DNA and amino acid sequence analysis and comparison | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme overexpression, or enzyme downregulation by siRNA | Mus musculus |
additional information | enzyme overexpression, or enzyme downregulation by siRNA | Rattus norvegicus |
additional information | enzyme overexpression, or enzyme downregulation by siRNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | Mus musculus | - |
2-oxoglutarate + CO2 + NADH + H+ | - |
? | |
isocitrate + NAD+ | Rattus norvegicus | - |
2-oxoglutarate + CO2 + NADH + H+ | - |
? | |
isocitrate + NAD+ | Homo sapiens | - |
2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50213 | - |
- |
Mus musculus | Q9D6R2 | - |
- |
Rattus norvegicus | Q99NA5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AGS cell | - |
Homo sapiens | - |
BEL-7404 cell | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Homo sapiens | - |
Chang liver cell | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
additional information | ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit | Mus musculus | - |
additional information | ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit | Rattus norvegicus | - |
additional information | ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit | Homo sapiens | - |
skeletal muscle | - |
Mus musculus | - |
skeletal muscle | - |
Rattus norvegicus | - |
skeletal muscle | - |
Homo sapiens | - |
small intestine | - |
Mus musculus | - |
small intestine | - |
Rattus norvegicus | - |
small intestine | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
spleen | - |
Rattus norvegicus | - |
spleen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | - |
Mus musculus | 2-oxoglutarate + CO2 + NADH + H+ | - |
? | |
isocitrate + NAD+ | - |
Rattus norvegicus | 2-oxoglutarate + CO2 + NADH + H+ | - |
? | |
isocitrate + NAD+ | - |
Homo sapiens | 2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDH3alpha | - |
Mus musculus |
IDH3alpha | - |
Rattus norvegicus |
IDH3alpha | - |
Homo sapiens |
isocitrate dehydrogenase 3alpha subunit | - |
Mus musculus |
isocitrate dehydrogenase 3alpha subunit | - |
Rattus norvegicus |
isocitrate dehydrogenase 3alpha subunit | - |
Homo sapiens |
NAD+-dependent isocitrate dehydrogenase 3 | - |
Mus musculus |
NAD+-dependent isocitrate dehydrogenase 3 | - |
Rattus norvegicus |
NAD+-dependent isocitrate dehydrogenase 3 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NAD+ | - |
Rattus norvegicus | |
NAD+ | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion | up |
Rattus norvegicus | aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion | up |
Homo sapiens | aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion | up |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Akt pathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1 | Mus musculus |
malfunction | overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1 | Rattus norvegicus |
malfunction | overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1 | Homo sapiens |
physiological function | IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B) | Mus musculus |
physiological function | IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B) | Rattus norvegicus |
physiological function | IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B) | Homo sapiens |