Cloned (Comment) | Organism |
---|---|
gene IDH3A, real-time PCR expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | NAD-IDHalpha knockdown by shRNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tributyltin | TBT, active in NT2/D1 carcinoma cells, overview. At nanomoler concentrations, tributyltin actions are mediated by genomic pathways via peroxisome proliferator-activated receptor gamma/retinoid X receptor, PPAR/RXR. Binding and in silico docking simulation analysis, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | Homo sapiens | - |
2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50213 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
NT2/D1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | - |
Homo sapiens | 2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hNAD-IDHalpha | - |
Homo sapiens |
IDH3A | - |
Homo sapiens |
IDH3alpha | - |
Homo sapiens |
NAD-dependent isocitrate dehydrogenase | - |
Homo sapiens |
NAD-IDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | specific for | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | NAD-IDH is a key enzyme in the tricarboxylic acid cycle | Homo sapiens |
additional information | homology modeling and docking studies of the human NAD-IDHalpha, overview | Homo sapiens |