KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.054 | - |
4-phospho-D-threonate | pH 8.0, 25°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.12 | - |
4-phospho-D-threonate | pH 8.0, 25°C | Cupriavidus necator | |
0.19 | - |
4-hydroxy-L-threonine 4-phosphate | pH 8.0, 25°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.2 | - |
4-hydroxy-L-threonine 4-phosphate | pH 8.0, 25°C | Cupriavidus necator |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cupriavidus necator | Q0K4F5 | - |
- |
Cupriavidus necator DSM 428 | Q0K4F5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | P58718 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | P58718 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-dehydro-4-phospho-D-erythronate | - |
Cupriavidus necator | glycerone phosphate + CO2 | spontaneous reaction | ? | |
3-dehydro-4-phospho-D-erythronate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | glycerone phosphate + CO2 | spontaneous reaction | ? | |
3-dehydro-4-phospho-D-erythronate | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | glycerone phosphate + CO2 | spontaneous reaction | ? | |
3-dehydro-4-phospho-D-erythronate | - |
Cupriavidus necator DSM 428 | glycerone phosphate + CO2 | spontaneous reaction | ? | |
4-hydroxy-L-threonine 4-phosphate + NAD+ | - |
Cupriavidus necator | 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-hydroxy-L-threonine 4-phosphate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-hydroxy-L-threonine 4-phosphate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-hydroxy-L-threonine 4-phosphate + NAD+ | - |
Cupriavidus necator DSM 428 | 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-erythronate + NAD+ | - |
Cupriavidus necator | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-erythronate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-erythronate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-erythronate + NAD+ | - |
Cupriavidus necator DSM 428 | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-threonate + NAD+ | - |
Cupriavidus necator | 3-dehydro-4-phospho-D-erythronate + NADH + H+ | - |
? | |
4-phospho-D-threonate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 3-dehydro-4-phospho-D-erythronate + NADH + H+ | - |
? | |
4-phospho-D-threonate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | 3-dehydro-4-phospho-D-erythronate + NADH + H+ | - |
? | |
4-phospho-D-threonate + NAD+ | - |
Cupriavidus necator DSM 428 | 3-dehydro-4-phospho-D-erythronate + NADH + H+ | - |
? | |
4-phospho-D-threonate + NAD+ | - |
Cupriavidus necator | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-threonate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-threonate + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? | |
4-phospho-D-threonate + NAD+ | - |
Cupriavidus necator DSM 428 | glycerone phosphate + CO2 + NADH + H+ | overall reaction | ? |
Synonyms | Comment | Organism |
---|---|---|
D-threonate 4-phosphate dehydrogenase | - |
Cupriavidus necator |
D-threonate 4-phosphate dehydrogenase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
DUF1537 | - |
Cupriavidus necator |
DUF1537 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
pdxA2 | - |
Cupriavidus necator |
pdxA2 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
4-hydroxy-L-threonine 4-phosphate | pH 8.0, 25°C | Cupriavidus necator | |
0.37 | - |
4-hydroxy-L-threonine 4-phosphate | pH 8.0, 25°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
3.4 | - |
4-phospho-D-threonate | pH 8.0, 25°C | Cupriavidus necator | |
8.9 | - |
4-phospho-D-threonate | pH 8.0, 25°C | Salmonella enterica subsp. enterica serovar Typhimurium |
General Information | Comment | Organism |
---|---|---|
physiological function | members of the DUF1537 family are ATP-dependent kinases that participate in catabolic pathways for four-carbon acid sugars. PdxA2 participates in a pathway for the conversion of D-threonate to dihydroxyacetone phosphate and CO2. A strain lacking PdxA2 activity is unable to use D-threonate as a carbon source | Cupriavidus necator |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.8 | - |
4-hydroxy-L-threonine 4-phosphate | pH 8.0, 25°C | Cupriavidus necator | |
1.9 | - |
4-hydroxy-L-threonine 4-phosphate | pH 8.0, 25°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
29 | - |
4-phospho-D-threonate | pH 8.0, 25°C | Cupriavidus necator | |
160 | - |
4-phospho-D-threonate | pH 8.0, 25°C | Salmonella enterica subsp. enterica serovar Typhimurium |