Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NADP+ | Rattus norvegicus | - |
pyruvate + CO2 + NADPH + H+ | - |
r | |
pyruvate + CO2 + NADPH + H+ | Rattus norvegicus | - |
(S)-malate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NADP+ | - |
Rattus norvegicus | pyruvate + CO2 + NADPH + H+ | - |
r | |
pyruvate + CO2 + NADPH + H+ | - |
Rattus norvegicus | (S)-malate + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
malic enzyme 1 | - |
Rattus norvegicus |
ME1 | - |
Rattus norvegicus |
NADPH-dependent malic enzyme 1 | - |
Rattus norvegicus |
NADPH-dependent ME1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | transverse aortic constriction induces elevated enzyme content in hearts. Enzyme expression is increased in hypertrophied rats heart | up |
General Information | Comment | Organism |
---|---|---|
malfunction | suppressing increased enzyme expression in hypertrophied rat hearts reduces pyruvate carboxylation thereby normalizing anaplerosis, restoring GSH content, and reducing lactate accumulation. Reducing the enzyme induces favorable metabolic shifts for carbohydrate oxidation, improving intracellular redox state and enhanced cardiac performance in pathological hypertrophy | Rattus norvegicus |