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Literature summary for 1.1.1.40 extracted from

  • Lahey, R.; Carley, A.N.; Wang, X.; Glass, C.E.; Accola, K.D.; Silvestry, S.; ODonnell, J.M.; Lewandowski, E.D.
    Enhanced redox state and efficiency of glucose oxidation with miR based suppression of maladaptive NADPH-dependent malic enzyme 1 expression in hypertrophied hearts (2018), Circ. Res., 122, 836-845 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NADP+ Rattus norvegicus
-
pyruvate + CO2 + NADPH + H+
-
r
pyruvate + CO2 + NADPH + H+ Rattus norvegicus
-
(S)-malate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
Rattus norvegicus pyruvate + CO2 + NADPH + H+
-
r
pyruvate + CO2 + NADPH + H+
-
Rattus norvegicus (S)-malate + NADP+
-
r

Synonyms

Synonyms Comment Organism
malic enzyme 1
-
Rattus norvegicus
ME1
-
Rattus norvegicus
NADPH-dependent malic enzyme 1
-
Rattus norvegicus
NADPH-dependent ME1
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus transverse aortic constriction induces elevated enzyme content in hearts. Enzyme expression is increased in hypertrophied rats heart up

General Information

General Information Comment Organism
malfunction suppressing increased enzyme expression in hypertrophied rat hearts reduces pyruvate carboxylation thereby normalizing anaplerosis, restoring GSH content, and reducing lactate accumulation. Reducing the enzyme induces favorable metabolic shifts for carbohydrate oxidation, improving intracellular redox state and enhanced cardiac performance in pathological hypertrophy Rattus norvegicus