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Literature summary for 1.1.1.4 extracted from

  • Dias, B.D.C.; Lima, M.E.D.N.V.; Vollu, R.E.; da Mota, F.F.; da Silva, A.J.R.; de Castro, A.M.; Freire, D.M.G.; Seldin, L.
    2,3-Butanediol production by the non-pathogenic bacterium Paenibacillus brasilensis (2018), Appl. Microbiol. Biotechnol., 102, 8773-8782 .
    View publication on PubMed
Search for more literature for 1.1.1.4

Application

Application Comment Organism
synthesis Paenibacillus brasilensis produces 2,3-butanediol (2,3-BDO) and can be utilized for large scale production Paenibacillus brasilensis

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Paenibacillus brasilensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R,R)-butane-2,3-diol + NAD+ Paenibacillus brasilensis
-
 (R)-acetoin + NADH + H+
-
 ?
(R,R)-butane-2,3-diol + NAD+ Paenibacillus brasilensis PB24
-
 (R)-acetoin + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Paenibacillus brasilensis A0A3Q8GZQ4
-
-
Paenibacillus brasilensis PB24 A0A3Q8GZQ4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R,R)-butane-2,3-diol + NAD+
-
 Paenibacillus brasilensis (R)-acetoin + NADH + H+
-
 ?
(R,R)-butane-2,3-diol + NAD+
-
 Paenibacillus brasilensis PB24 (R)-acetoin + NADH + H+
-
 ?
additional information production of R,R- and meso-2,3-BDO by Paenibacillus brasilensis strain PB24 grown in the modified YEPD medium, pH 6.3, 32°C, up to 72 h Paenibacillus brasilensis ?
-
-
additional information production of R,R- and meso-2,3-BDO by Paenibacillus brasilensis strain PB24 grown in the modified YEPD medium, pH 6.3, 32°C, up to 72 h Paenibacillus brasilensis PB24 ?
-
-

Synonyms

Synonyms Comment Organism
ButB
-
 Paenibacillus brasilensis
MF996569 locus name Paenibacillus brasilensis
PB24_3312
-
 Paenibacillus brasilensis
R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase
-
 Paenibacillus brasilensis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Paenibacillus brasilensis

General Information

General Information Comment Organism
metabolism the proposed pathway from glucose to 2,3-butanediol in Paenibacillus brasilensis involves the enzyme, overview Paenibacillus brasilensis
physiological function Paenibacillus brasilensis produces 2,3-butanediol (2,3-BDO). And although the gene encoding (S,S)-2,3-butanediol dehydrogenase (EC 1.1.1.76) is found in the genome of Paenibacillus brasilensis strain PB24, only R,R-2,3-butanediol ((R,R)-2,3-butanediol dehydrogenase, EC 1.1.1.4) and meso-2,3-butanediol are detected by gas chromatography under the growth conditions tested. The enzyme is multifunctional as R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase Paenibacillus brasilensis