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Literature summary for 1.1.1.39 extracted from

  • Lin, R.C.; Davis, E.J.
    Malic enzymes of rabbit heart mitochondria. Separation and comparison of some characteristics of a nicotinamide adenine dinucleotide-preferring and a nicotinamide adenine dinuclweotide phosphate-specific enzyme (1974), J. Biol. Chem., 249, 3867-3875.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ATP competitive with respect to (S)-malate Oryctolagus cuniculus
oxalate
-
Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
NAD+ activation by Mn2+ Oryctolagus cuniculus
0.82
-
NAD+ activation by Mg2+ Oryctolagus cuniculus
1.32
-
NADP+ activation by Mn2+ Oryctolagus cuniculus
3.2
-
(S)-malate with NAD+ as coenzyme, activation by Mn2+ Oryctolagus cuniculus
6.12
-
NADP+ activation by Mg2+ Oryctolagus cuniculus
9.8
-
(S)-malate with NADP+ as coenzyme, activation by Mn2+ Oryctolagus cuniculus
13
-
(S)-malate with NAD+ as coenzyme, activation by Mg2+ Oryctolagus cuniculus
22.5
-
(S)-malate with NADP+ as coenzyme, activation by Mg2+ Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Oryctolagus cuniculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mn2+ or Mg2+ required Oryctolagus cuniculus
Mg2+ Km with NAD+: 4.25 mM, Km with NADP+: 13.3 mM Oryctolagus cuniculus
Mn2+ Mn2+ or Mg2+ required Oryctolagus cuniculus
Mn2+ Km with NAD+: 0.14 mM, Km with NADP+: 0.81 mM Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
270000
-
gel filtration Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
Oryctolagus cuniculus pyruvate + CO2 + NADPH
-
ir
malate + NAD+
-
Oryctolagus cuniculus pyruvate + CO2 + NADH + H+
-
ir
additional information no decarboxylation of oxaloacetate Oryctolagus cuniculus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Oryctolagus cuniculus
NADP+
-
Oryctolagus cuniculus