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Literature summary for 1.1.1.37 extracted from

  • Smith, S.
    Moonlighting NAD+ malate dehydrogenase is essential for chloroplast biogenesis (2018), Plant Cell, 30, 1663-1664 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast chloroplast envelope inner membrane Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Arabidopsis thaliana
-
oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH + H+ Arabidopsis thaliana
-
(S)-malate + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Arabidopsis thaliana oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH + H+
-
Arabidopsis thaliana (S)-malate + NAD+
-
r

Synonyms

Synonyms Comment Organism
MDH
-
Arabidopsis thaliana
NAD+ malate dehydrogenase
-
Arabidopsis thaliana
pdNAD-MDH
-
Arabidopsis thaliana
plastidial NAD+-dependent malate dehydrogenase
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Arabidopsis thaliana
NADH
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction Arabidopsis enzyme knockout mutants are embryo-lethal, and a line with lowered enzyme from gene silencing has poor growth, pale leaves, disorganized chloroplasts, and low nighttime respiration Arabidopsis thaliana
physiological function the enzyme is essential during embryogenesis and seed development. The protein, but not its NAD+-dependent malate dehydrogenase enzyme activity, is required for plastid development. The enzyme is required to stabilize filamentous temperature sensitive protease FtsH12 Arabidopsis thaliana