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Literature summary for 1.1.1.37 extracted from

  • Plancarte, A.; Nava, G.; Mendoza-Hernandez, G.
    Purification, properties, and kinetic studies of cytoplasmic malate dehydrogenase from Taenia solium cysticerci (2009), Parasitol. Res., 105, 175-183.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
arsenate uncompetitive inhibition Taenia solium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0024
-
oxaloacetate
-
Taenia solium
0.048
-
NADH
-
Taenia solium
0.05
-
NAD+
-
Taenia solium
0.215
-
(S)-malate
-
Taenia solium

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Taenia solium 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
2 * 32000, native enzyme, gel filtration Taenia solium
64000
-
native enzyme, gel filtration Taenia solium

Organism

Organism UniProt Comment Textmining
Taenia solium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate fractionation, CM-Sepharose column chromatography, and Blue Sepharose column chromatography Taenia solium

Source Tissue

Source Tissue Comment Organism Textmining
cysticercus
-
Taenia solium
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.054
-
crude extract, in the reduction of oxaloacetate Taenia solium
2.615
-
48.3fold purified enzyme, in the reduction of oxaloacetate Taenia solium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Taenia solium oxaloacetate + NADH + H+
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 32000, native enzyme, gel filtration Taenia solium

Synonyms

Synonyms Comment Organism
cMDH
-
Taenia solium
L-malate: NAD oxidoreductase
-
Taenia solium

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
10 45 the parasite enzyme activity is not affected in a broad temperature range (from 10°C to 45°C), the enzyme is also stable at 20°C and 37°C over a 30 min period Taenia solium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
for oxaloacetate reduction Taenia solium
9.6
-
for (S)-malate oxidation Taenia solium

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.8 8.5 in the forward reaction Taenia solium

Cofactor

Cofactor Comment Organism Structure
additional information can also use 3-acetylpyridine-adenine and nicotinamide guanine as cofactors but with less specificity than NAD+ Taenia solium
NAD+
-
Taenia solium

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
8.2
-
arsenate for the oxaloacetate reduction Taenia solium
77
-
arsenate for the malate oxidation Taenia solium

pI Value

Organism Comment pI Value Maximum pI Value
Taenia solium isoelectric focusing
-
8.7