Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arsenate | uncompetitive inhibition | Taenia solium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0024 | - |
oxaloacetate | - |
Taenia solium | |
0.048 | - |
NADH | - |
Taenia solium | |
0.05 | - |
NAD+ | - |
Taenia solium | |
0.215 | - |
(S)-malate | - |
Taenia solium |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Taenia solium | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
2 * 32000, native enzyme, gel filtration | Taenia solium |
64000 | - |
native enzyme, gel filtration | Taenia solium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taenia solium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate fractionation, CM-Sepharose column chromatography, and Blue Sepharose column chromatography | Taenia solium |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cysticercus | - |
Taenia solium | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.054 | - |
crude extract, in the reduction of oxaloacetate | Taenia solium |
2.615 | - |
48.3fold purified enzyme, in the reduction of oxaloacetate | Taenia solium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NAD+ | - |
Taenia solium | oxaloacetate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 32000, native enzyme, gel filtration | Taenia solium |
Synonyms | Comment | Organism |
---|---|---|
cMDH | - |
Taenia solium |
L-malate: NAD oxidoreductase | - |
Taenia solium |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
10 | 45 | the parasite enzyme activity is not affected in a broad temperature range (from 10°C to 45°C), the enzyme is also stable at 20°C and 37°C over a 30 min period | Taenia solium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
for oxaloacetate reduction | Taenia solium |
9.6 | - |
for (S)-malate oxidation | Taenia solium |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6.8 | 8.5 | in the forward reaction | Taenia solium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | can also use 3-acetylpyridine-adenine and nicotinamide guanine as cofactors but with less specificity than NAD+ | Taenia solium | |
NAD+ | - |
Taenia solium |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
8.2 | - |
arsenate | for the oxaloacetate reduction | Taenia solium | |
77 | - |
arsenate | for the malate oxidation | Taenia solium |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Taenia solium | isoelectric focusing | - |
8.7 |