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Literature summary for 1.1.1.37 extracted from
- Malate dehydrogenase: Distribution, function and properties (1998), Gen. Physiol. Biophys., 17, 193-210.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | activation of the enzyme obtained by increasing the salt concentration to 3 M NaCl/l | Kitasatospora aureofaciens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA encoding mitochondrial malate dehydrogenase sequenced | Eucalyptus globulus |
| gene encoding mitochondrial isoenzyme of MDH is present in a single copy in genomic DNA | Saccharomyces cerevisiae |
| gene for tMDH expressed in Escherichia coli and sequence reported | Thermus thermophilus |
| structural gene expressed in Escherichia coli expression vector pET11a, large amounts of soluble but inactive form of the enzyme produced upon its induction | Haloarcula marismortui |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Thermus thermophilus |
- |
Escherichia coli |
- |
Zea mays |
- |
Kitasatospora aureofaciens |
General Stability
| General Stability | Organism |
|---|---|
| only stable in highly concentrated solutions of certain salts | Haloarcula marismortui |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chloroplast | - |
Euglena gracilis | 9507 | - |
| chloroplast | - |
Zea mays | 9507 | - |
| cytoplasm | - |
Mus musculus | 5737 | - |
| cytoplasm | - |
Sus scrofa | 5737 | - |
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Thermus thermophilus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
| cytosol | - |
Euglena gracilis | 5829 | - |
| glyoxysome | - |
Euglena gracilis | 9514 | - |
| glyoxysome | - |
Citrullus lanatus | 9514 | - |
| microbody | - |
Euglena gracilis | 42579 | - |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Thermus thermophilus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Sus scrofa | 5739 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
| mitochondrion | - |
Citrullus lanatus | 5739 | - |
| mitochondrion | outer membrane, intermembrane space, inner membrane, matrix | Euglena gracilis | 5739 | - |
| peroxisome | - |
Euglena gracilis | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
2 * 35000, SDS-PAGE | Thermus thermophilus |
| 38000 | - |
2 * 38000 | Eucalyptus globulus |
| 70000 | - |
- |
Rattus norvegicus |
| 70000 | - |
- |
Methanothermus fervidus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malate + NAD+ | Haloarcula marismortui | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Mus musculus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Thermus thermophilus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Escherichia coli | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Rattus norvegicus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Sus scrofa | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Saccharomyces cerevisiae | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Euglena gracilis | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Zea mays | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Sulfolobus acidocaldarius | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Kitasatospora aureofaciens | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Methanothermus fervidus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Citrullus lanatus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Nitzschia alba | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Eucalyptus globulus | - |
oxaloacetate + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Citrullus lanatus | - |
watermelon | - |
| Escherichia coli | - |
- |
- |
| Eucalyptus globulus | - |
- |
- |
| Euglena gracilis | - |
- |
- |
| Haloarcula marismortui | - |
- |
- |
| Kitasatospora aureofaciens | - |
- |
- |
| Methanothermus fervidus | - |
- |
- |
| Mus musculus | - |
mouse | - |
| Nitzschia alba | - |
marine diatom | - |
| Rattus norvegicus | - |
rat | - |
| Saccharomyces cerevisiae | - |
yeast | - |
| Sulfolobus acidocaldarius | - |
- |
- |
| Sus scrofa | - |
pig | - |
| Thermus thermophilus | - |
- |
- |
| Zea mays | - |
maize | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Thermus thermophilus |
- |
Zea mays |
- |
Kitasatospora aureofaciens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NAD+ | - |
Haloarcula marismortui | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Mus musculus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Thermus thermophilus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Rattus norvegicus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Saccharomyces cerevisiae | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Euglena gracilis | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Zea mays | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Sulfolobus acidocaldarius | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Kitasatospora aureofaciens | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Methanothermus fervidus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Citrullus lanatus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Nitzschia alba | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Eucalyptus globulus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Haloarcula marismortui | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Mus musculus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Thermus thermophilus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Rattus norvegicus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Saccharomyces cerevisiae | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Euglena gracilis | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Zea mays | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Sulfolobus acidocaldarius | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Kitasatospora aureofaciens | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Methanothermus fervidus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Citrullus lanatus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Nitzschia alba | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Eucalyptus globulus | oxaloacetate + NADH + H+ | - |
r | |
| oxaloacetate + NADH | - |
Haloarcula marismortui | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Mus musculus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Thermus thermophilus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Escherichia coli | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Rattus norvegicus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Sus scrofa | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Saccharomyces cerevisiae | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Euglena gracilis | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Zea mays | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Sulfolobus acidocaldarius | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Kitasatospora aureofaciens | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Methanothermus fervidus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Citrullus lanatus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Nitzschia alba | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Eucalyptus globulus | L-malate + NAD+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Sus scrofa |
| dimer | - |
Saccharomyces cerevisiae |
| dimer | - |
Euglena gracilis |
| dimer | 2 * 35000, SDS-PAGE | Thermus thermophilus |
| dimer | 2 * 38000 | Eucalyptus globulus |
| octamer | - |
Nitzschia alba |
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