Literature summary for 1.1.1.363 extracted from

Szweda, L.I.; Uchida, K.; Tsai, L.; Stadtman, E.R.
Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine (1993), J. Biol. Chem., 268, 3342-3347.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-hydroxy-2-nonenal	pseudo first-order loss of enzyme activity. The pH dependence of the inactivation rate exhibits an inflection around pH 10, and the enzyme is protected from inactivation by glucose 6-phosphate. Loss of enzyme activity corresponds with the formation of one carbonyl function per enzyme subunit and the appearance of a lysine-4-hydroxy-2-nonenal adduct	Leuconostoc mesenteroides

Organism

Organism	UniProt	Comment	Textmining
Leuconostoc mesenteroides	-	-	-

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Release 2023.1 (January 2023)