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Literature summary for 1.1.1.363 extracted from

  • Levy, H.R.; Christoff, M.; Ingulli, J.; Ho, E.M.
    Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides: revised kinetic mechanism and kinetics of ATP inhibition (1983), Arch. Biochem. Biophys., 222, 473-488.
    View publication on PubMed
Search for more literature for 1.1.1.363

Inhibitors

Inhibitors Comment Organism Structure
ATP the kinetics of ATP inhibition of the NAD+- and NADP+-linked reactions examined at pH 6.2 and pH 7.8. The results are interpreted in terms of ATP addition to binary enzyme-coenzyme and enzyme-glucose 6-phosphate complexes Leuconostoc mesenteroides
NAD+
-
 Leuconostoc mesenteroides
NADP+
-
 Leuconostoc mesenteroides
NADPH
-
 Leuconostoc mesenteroides

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0042
-
 NADP+ 25°C, pH 6.2 Leuconostoc mesenteroides
0.0043
-
 NADP+ 25°C, pH 6.7 Leuconostoc mesenteroides
0.0057
-
 NADP+ 25°C, pH 7.2 Leuconostoc mesenteroides
0.05
-
 D-glucose 6-phosphate 25°C, pH 6.2, NADP+-linked reaction Leuconostoc mesenteroides
0.053
-
 D-glucose 6-phosphate 25°C, pH 7.8, NAD+-linked reaction Leuconostoc mesenteroides
0.063
-
 D-glucose 6-phosphate 25°C, pH 6.7, NADP+-linked reaction Leuconostoc mesenteroides
0.066
-
 D-glucose 6-phosphate 25°C, pH 6.8, NAD+-linked reaction Leuconostoc mesenteroides
0.068
-
 D-glucose 6-phosphate 25°C, pH 6.3, NAD+-linked reaction Leuconostoc mesenteroides
0.081
-
 D-glucose 6-phosphate 25°C, pH 7.2, NADP+-linked reaction Leuconostoc mesenteroides
0.106
-
 NAD+ 25°C, pH 7.8 Leuconostoc mesenteroides
0.359
-
 NAD+ 25°C, pH 6.8 Leuconostoc mesenteroides
0.432
-
 NAD+ 25°C, pH 6.3 Leuconostoc mesenteroides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + NAD+ Leuconostoc mesenteroides
-
 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
 ?
D-glucose 6-phosphate + NADP+ Leuconostoc mesenteroides
-
 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Leuconostoc mesenteroides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NAD+
-
 Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
 ?
D-glucose 6-phosphate + NAD+ steady-state random mechanism Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
 ?
D-glucose 6-phosphate + NADP+
-
 Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?
D-glucose 6-phosphate + NADP+ ordered, sequential mechanism. NADP+ binds first Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Leuconostoc mesenteroides

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Leuconostoc mesenteroides
NADP+
-
 Leuconostoc mesenteroides

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0037
-
 NADP+ 25°C, pH 6.7 Leuconostoc mesenteroides
0.0039
-
 NADP+ 25°C, pH 6.2 Leuconostoc mesenteroides
0.005
-
 NADP+ 25°C, pH 7.2 Leuconostoc mesenteroides
0.006
-
 NADPH 25°C, pH 6.2 Leuconostoc mesenteroides
0.038
-
 NADPH 25°C, pH 7.2 Leuconostoc mesenteroides
0.76
-
 NAD+ 25°C, pH 7.8 Leuconostoc mesenteroides
0.95
-
 NAD+ 25°C, pH 6.8 Leuconostoc mesenteroides
1.3
-
 NAD+ 25°C, pH 6.3 Leuconostoc mesenteroides