Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.355 extracted from

  • Sucipto, H.; Kudo, F.; Eguchi, T.
    The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK (2012), Angew. Chem. Int. Ed. Engl., 51, 3428-3431.
    View publication on PubMed
Search for more literature for 1.1.1.355

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces kanamyceticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2'-dehydrokanamycin A + NADPH + H+ Streptomyces kanamyceticus the enzyme is involved in the conversion of kanamycin B to kanamycin A. Kanamycin is a clinically important aminoglycoside antibiotic kanamycin A + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces kanamyceticus Q2MFU6
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces kanamyceticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-dehydrokanamycin A + NADPH + H+ the enzyme is involved in the conversion of kanamycin B to kanamycin A. Kanamycin is a clinically important aminoglycoside antibiotic Streptomyces kanamyceticus kanamycin A + NADP+
-
 ?
2'-dehydrokanamycin A + NADPH + H+ i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-a-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside Streptomyces kanamyceticus kanamycin A + NADP+ i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-a-D-arabino-hexopyranosyl-2-ulose)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside ?

Synonyms

Synonyms Comment Organism
kanK
-
 Streptomyces kanamyceticus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Streptomyces kanamyceticus