BRENDA - Enzyme Database show
show all sequences of 1.1.1.352

A new inhibitor of 5-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum

Sakuno, E.; Yabe, K.; Hamasaki, T.; Nakajima, H.; J. Nat. Prod. 63, 1677-1678 (2000)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione
TAEMC161, specific inhibitor
Aspergillus parasiticus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Aspergillus parasiticus
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aspergillus parasiticus
-
-
-
Aspergillus parasiticus NIAH-26
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate precipitation, butyl-Toyopearl 650 M column chromatography
Aspergillus parasiticus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
mycelium
-
Aspergillus parasiticus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(1'S,5'S)-hydroxyaverantin + NAD+
-
723018
Aspergillus parasiticus
5'-oxoaverantin + NADH + H+
-
-
-
?
(1'S,5'S)-hydroxyaverantin + NAD+
-
723018
Aspergillus parasiticus NIAH-26
5'-oxoaverantin + NADH + H+
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Aspergillus parasiticus
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.25
-
in 50 mM Tris-HCl buffer (pH 8.5), at 33C
Aspergillus parasiticus
4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Aspergillus parasiticus
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.25
-
in 50 mM Tris-HCl buffer (pH 8.5), at 33C
Aspergillus parasiticus
4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4,6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano-[7,6-e]cyclopenta[c]2H-pyran-1,9-dione
TAEMC161, specific inhibitor
Aspergillus parasiticus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Aspergillus parasiticus
5829
-
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate precipitation, butyl-Toyopearl 650 M column chromatography
Aspergillus parasiticus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
mycelium
-
Aspergillus parasiticus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(1'S,5'S)-hydroxyaverantin + NAD+
-
723018
Aspergillus parasiticus
5'-oxoaverantin + NADH + H+
-
-
-
?
(1'S,5'S)-hydroxyaverantin + NAD+
-
723018
Aspergillus parasiticus NIAH-26
5'-oxoaverantin + NADH + H+
-
-
-
?
Other publictions for EC 1.1.1.352
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721863
Sakuno
Purification and gene cloning ...
Lactobacillus brevis, Lactobacillus brevis IFO 12005
Biosci. Biotechnol. Biochem.
72
724-734
2008
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-
1
-
-
-
-
1
-
-
4
2
-
7
-
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1
-
-
-
2
-
4
1
1
-
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1
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1
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1
1
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1
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4
2
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1
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2
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4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
721331
Sakuno
Involvement of two cytosolic e ...
Aspergillus parasiticus, Aspergillus parasiticus NIAH-26
Appl. Environ. Microbiol.
69
6418-6426
2003
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-
-
-
-
-
-
1
1
-
3
2
-
10
-
-
1
-
-
1
2
-
2
1
1
1
-
-
1
-
-
1
-
-
-
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1
-
-
-
-
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-
1
1
-
3
2
-
-
-
1
-
1
2
-
2
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
721327
Chang
adhA in Aspergillus parasiticu ...
Aspergillus parasiticus, Aspergillus parasiticus SRRC 2043, Aspergillus parasiticus SU-1
Appl. Environ. Microbiol.
66
4715-4719
2000
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-
-
-
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3
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1
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3
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1
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3
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-
-
-
-
-
-
-
-
-
-
-
723018
Sakuno
A new inhibitor of 5-hydroxyav ...
Aspergillus parasiticus, Aspergillus parasiticus NIAH-26
J. Nat. Prod.
63
1677-1678
2000
-
-
-
-
-
-
1
-
1
-
-
-
-
10
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
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-
1
1
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1
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-
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-
1
-
1
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2
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