Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae strain YSC5023 | Ginkgo biloba |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Ginkgo biloba | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ginkgo biloba | A0A385FV32 | - |
- |
Ginkgo biloba | A0A3S8X7U0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cone | - |
Ginkgo biloba | - |
cone | strong expression of isoform HMGR2 in female strobili, lowest expression of isoform HMGR2 in male strobili | Ginkgo biloba | - |
leaf | strong expression of isoform HMGR2 in leaves | Ginkgo biloba | - |
leaf | strongest expression of isoform HMGR3 in leaves | Ginkgo biloba | - |
root | - |
Ginkgo biloba | - |
root | lowest expression of isoform HMGR3 | Ginkgo biloba | - |
stem | - |
Ginkgo biloba | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Ginkgo biloba | (R)-mevalonate + CoA + 2 NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 61500, isoform HMGR3, calculated from amino acid sequence | Ginkgo biloba |
? | x * 61700, isoform HMGR2, calculated from amino acid sequence | Ginkgo biloba |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase | - |
Ginkgo biloba |
HMGR2 | isoform | Ginkgo biloba |
HMGR3 | isoform | Ginkgo biloba |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Ginkgo biloba | isoform HMGR3, calculated from amino acid sequence | - |
6.9 |
Ginkgo biloba | isoform HMGR2, calculated from amino acid sequence | - |
8.2 |
Organism | Comment | Expression |
---|---|---|
Ginkgo biloba | the expression level of isoform HMGR3 is considerably downregulated under dark treatment, that is, 8% of the control at 24 h after treatment | down |
Ginkgo biloba | the isoform HMGR2 expression is substantially depressed under dark treatment and is 90% lower than that of the control at 8 h after treatment. Methyl jasmonate treatment causes the continuous downregulation of isoform HMGR2 transcription level at 5% that of the control at 4 days after treatment. The expression level of isoform HMGR2 is downregulated in response to abscisic acid treatment, yielding a value 90% lower than that of the control at 5 days after treatment | down |
Ginkgo biloba | at 8 h after cold treatment, the transcription level of isoform HMGR3 sharply increases to a peak value that is 4.5fold that of the control. Isoform HMGR3 expression reaches the maximum value, which is 1.67fold that of the control at 4 days after treatment with methyl jasmonate. Abscisic acid treatment shows similarly increasing values until a moderate peak at 2 days after treatment. Salicylic acid and ethanol treatments distinctly upregulated the expression of isoform HMGR3 with the peak appearing at 5 days after treatment. The former increases the expression by 3.74fold and the latter by 34.6fold compared with that of the control | up |
Ginkgo biloba | under cold treatment, the isoform HMGR2 expression is enhanced by 6.6fold compared with that of the control, and reaches the highest level at 48 h. Under salicylic acid treatment, the expression level of isoform HMGR2 initially decreases first and then increases, and the value is 80% higher than that of the control at 3 days after treatment. Ethanol treatment induces the transcript of isoform HMGR2, which continually increases and reaches the highest expression value at 978% higher than that of the control at 4 days after treatment | up |