Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04035 | - |
- |
Mus musculus | Q01237 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Hepa-1 cell | - |
Mus musculus | - |
NIH-3T3 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl-CoA reductase | - |
Homo sapiens |
3-hydroxy-3-methylglutaryl-CoA reductase | - |
Mus musculus |
HMGCR | - |
Homo sapiens |
HMGCR | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | increased Hmgcr mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription | down |
Mus musculus | increased Hmgcr mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription | down |
Homo sapiens | increased Hmgcr mRNA levels after serum starvation | up |
Mus musculus | increased Hmgcr mRNA levels after serum starvation | up |
General Information | Comment | Organism |
---|---|---|
metabolism | rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis | Homo sapiens |
metabolism | rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis | Mus musculus |