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Literature summary for 1.1.1.34 extracted from

  • Ando, H.; Horibata, Y.; Aoyama, C.; Shimizu, H.; Shinohara, Y.; Yamashita, S.; Sugimoto, H.
    Side-chain oxysterols suppress the transcription of CTP phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation (2019), J. Steroid Biochem. Mol. Biol., 195, 105482 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P04035
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Mus musculus Q01237
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-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Hepa-1 cell
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Mus musculus
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NIH-3T3 cell
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Mus musculus
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Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-CoA reductase
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Homo sapiens
3-hydroxy-3-methylglutaryl-CoA reductase
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Mus musculus
HMGCR
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Homo sapiens
HMGCR
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Mus musculus

Expression

Organism Comment Expression
Homo sapiens increased Hmgcr mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription down
Mus musculus increased Hmgcr mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription down
Homo sapiens increased Hmgcr mRNA levels after serum starvation up
Mus musculus increased Hmgcr mRNA levels after serum starvation up

General Information

General Information Comment Organism
metabolism rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis Homo sapiens
metabolism rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis Mus musculus