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Literature summary for 1.1.1.34 extracted from
- Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase (2012), Amino Acids, 43, 2015-2025.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AFGYVAE | - |
Homo sapiens |  |
| DFGYVAE | - |
Homo sapiens | |
| EFGYVAE | - |
Homo sapiens | |
| FFGYVAE | - |
Homo sapiens | |
| FFYVAE | - |
Homo sapiens | |
| FG-(4-fluoro)FVAE | - |
Homo sapiens | |
| FGYVAE | - |
Homo sapiens | |
| FPYVAE | - |
Homo sapiens | |
| GFGYVAE | - |
Homo sapiens | |
| IAVPTGVA | - |
Homo sapiens | |
| IFGYVAE | - |
Homo sapiens | |
| Ile-Ala-Val-Glu | - |
Homo sapiens | |
| Ile-Ala-Val-Pro-Gly-Glu-Val-Ala | - |
Homo sapiens | |
| Ile-Val-Ala-Glu | - |
Homo sapiens | |
| Leu-Pro-Tyr-Pro | - |
Homo sapiens | |
| LFGYVAE | - |
Homo sapiens | |
| additional information | design of highly potent and competitive inhibitory peptides for 3-hydroxy-3-methylglutaryl CoA reductase, no inhibition with SFGYVAG peptide | Homo sapiens | |
| PFGYVAE | - |
Homo sapiens | |
| SFGYVAE peptide | most active inhibitory peptide; shows high ability to inhibit HMGR by competitive inhibition with respect to (S)-3-hydroxy-3-methylglutaryl-CoA | Homo sapiens | |
| TFGYVAE | - |
Homo sapiens | |
| Tyr-Ala-Val-Glu | - |
Homo sapiens | |
| Tyr-Val-Ala-Glu | - |
Homo sapiens | |
| VFGYVAE | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Homo sapiens | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Homo sapiens | (R)-mevalonate + CoA + 2 NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-hydroxy-3-methylglutaryl CoA reductase | - |
Homo sapiens |
| HMG-CoA reductase | - |
Homo sapiens |
| HMGR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000012 | - |
SFGYVAE peptide | pH and temperature not specified in the publication | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000033 | - |
pH and temperature not specified in the publication | Homo sapiens | SFGYVAE peptide | |
| 0.00016 | - |
pH and temperature not specified in the publication | Homo sapiens | DFGYVAE | |
| 0.00024 | - |
pH and temperature not specified in the publication | Homo sapiens | EFGYVAE | |
| 0.00026 | - |
pH and temperature not specified in the publication | Homo sapiens | TFGYVAE | |
| 0.00027 | - |
pH and temperature not specified in the publication | Homo sapiens | GFGYVAE | |
| 0.00032 | - |
pH and temperature not specified in the publication | Homo sapiens | FFGYVAE | |
| 0.00035 | - |
pH and temperature not specified in the publication | Homo sapiens | IFGYVAE | |
| 0.00037 | - |
pH and temperature not specified in the publication | Homo sapiens | LFGYVAE | |
| 0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | FGYVAE | |
| 0.00043 | - |
pH and temperature not specified in the publication | Homo sapiens | PFGYVAE | |
| 0.00045 | - |
pH and temperature not specified in the publication | Homo sapiens | VFGYVAE | |
| 0.00049 | - |
pH and temperature not specified in the publication | Homo sapiens | AFGYVAE | |
| 0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | FPYVAE | |
| 0.0025 | - |
pH and temperature not specified in the publication | Homo sapiens | FFYVAE | |
| 0.0085 | - |
pH and temperature not specified in the publication | Homo sapiens | FG-(4-fluoro)FVAE | |
| 0.041 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Val-Ala-Glu | |
| 0.044 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Ala-Val-Glu | |
| 0.052 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Val-Ala-Glu | |
| 0.075 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala-Val-Glu | |
| 0.152 | - |
pH and temperature not specified in the publication | Homo sapiens | IAVPTGVA | |
| 0.201 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala-Val-Pro-Gly-Glu-Val-Ala | |
| 0.484 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Pro-Tyr-Pro | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is the major regulatory enzyme of cholesterol biosynthesis and the target enzyme of many investigations aimed at lowering the rate of cholesterol biosynthesis | Homo sapiens |
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