Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AFGYVAE | - |
Homo sapiens | |
DFGYVAE | - |
Homo sapiens | |
EFGYVAE | - |
Homo sapiens | |
FFGYVAE | - |
Homo sapiens | |
FFYVAE | - |
Homo sapiens | |
FG-(4-fluoro)FVAE | - |
Homo sapiens | |
FGYVAE | - |
Homo sapiens | |
FPYVAE | - |
Homo sapiens | |
GFGYVAE | - |
Homo sapiens | |
IAVPTGVA | - |
Homo sapiens | |
IFGYVAE | - |
Homo sapiens | |
Ile-Ala-Val-Glu | - |
Homo sapiens | |
Ile-Ala-Val-Pro-Gly-Glu-Val-Ala | - |
Homo sapiens | |
Ile-Val-Ala-Glu | - |
Homo sapiens | |
Leu-Pro-Tyr-Pro | - |
Homo sapiens | |
LFGYVAE | - |
Homo sapiens | |
additional information | design of highly potent and competitive inhibitory peptides for 3-hydroxy-3-methylglutaryl CoA reductase, no inhibition with SFGYVAG peptide | Homo sapiens | |
PFGYVAE | - |
Homo sapiens | |
SFGYVAE peptide | most active inhibitory peptide; shows high ability to inhibit HMGR by competitive inhibition with respect to (S)-3-hydroxy-3-methylglutaryl-CoA | Homo sapiens | |
TFGYVAE | - |
Homo sapiens | |
Tyr-Ala-Val-Glu | - |
Homo sapiens | |
Tyr-Val-Ala-Glu | - |
Homo sapiens | |
VFGYVAE | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Homo sapiens | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Homo sapiens | (R)-mevalonate + CoA + 2 NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl CoA reductase | - |
Homo sapiens |
HMG-CoA reductase | - |
Homo sapiens |
HMGR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000012 | - |
SFGYVAE peptide | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000033 | - |
pH and temperature not specified in the publication | Homo sapiens | SFGYVAE peptide | |
0.00016 | - |
pH and temperature not specified in the publication | Homo sapiens | DFGYVAE | |
0.00024 | - |
pH and temperature not specified in the publication | Homo sapiens | EFGYVAE | |
0.00026 | - |
pH and temperature not specified in the publication | Homo sapiens | TFGYVAE | |
0.00027 | - |
pH and temperature not specified in the publication | Homo sapiens | GFGYVAE | |
0.00032 | - |
pH and temperature not specified in the publication | Homo sapiens | FFGYVAE | |
0.00035 | - |
pH and temperature not specified in the publication | Homo sapiens | IFGYVAE | |
0.00037 | - |
pH and temperature not specified in the publication | Homo sapiens | LFGYVAE | |
0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | FGYVAE | |
0.00043 | - |
pH and temperature not specified in the publication | Homo sapiens | PFGYVAE | |
0.00045 | - |
pH and temperature not specified in the publication | Homo sapiens | VFGYVAE | |
0.00049 | - |
pH and temperature not specified in the publication | Homo sapiens | AFGYVAE | |
0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | FPYVAE | |
0.0025 | - |
pH and temperature not specified in the publication | Homo sapiens | FFYVAE | |
0.0085 | - |
pH and temperature not specified in the publication | Homo sapiens | FG-(4-fluoro)FVAE | |
0.041 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Val-Ala-Glu | |
0.044 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Ala-Val-Glu | |
0.052 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Val-Ala-Glu | |
0.075 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala-Val-Glu | |
0.152 | - |
pH and temperature not specified in the publication | Homo sapiens | IAVPTGVA | |
0.201 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala-Val-Pro-Gly-Glu-Val-Ala | |
0.484 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Pro-Tyr-Pro |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is the major regulatory enzyme of cholesterol biosynthesis and the target enzyme of many investigations aimed at lowering the rate of cholesterol biosynthesis | Homo sapiens |