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Literature summary for 1.1.1.34 extracted from
- HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi (2008), Stud. Mycol., 61, 61-66.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lovastatin | no effect of lovastatin on the growth curve of Hortaea werneckii in salt-free media, whereas remarkably reduced growth in the otherwise physiologically optimal medium containing 17% NaCl, an effect even more pronounced in hypersaline medium containing 25% NaCl. Inhibition of HMGR in vivo by lovastatin impairs the halotolerant character | Hortaea werneckii |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Saccharomyces cerevisiae | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Aspergillus amstelodami | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Aureobasidium pullulans | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Debaryomyces hansenii | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Hortaea werneckii | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Neophaeotheca triangularis | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Trimmatostroma salinum | |
| NaCl | specific HMGR activity is responsive to changes in NaCl concentrations. Minimal activity under optimal conditions and an increase in HMGR activities and protein levels under hyposaline and hypersaline conditions. HMGR activity is crucial for halotolerance as well as for the changes in protein prenylation in response to changing salinity | Wallemia ichthyophaga | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Saccharomyces cerevisiae | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Aspergillus amstelodami | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Aureobasidium pullulans | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Debaryomyces hansenii | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Hortaea werneckii | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Neophaeotheca triangularis | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Trimmatostroma salinum | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Wallemia ichthyophaga | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Saccharomyces cerevisiae MZKI K86 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Wallemia ichthyophaga EXF 994 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Neophaeotheca triangularis MZKI B741 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Aureobasidium pullulans MZKI B802 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Hortaea werneckii MZKI B736 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Aspergillus amstelodami MZKI A561 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Debaryomyces hansenii CBS 767 | - |
mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | Trimmatostroma salinum MZKI B734 | - |
mevalonate + CoA + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus amstelodami | - |
MZKI A561 | - |
| Aspergillus amstelodami MZKI A561 | - |
MZKI A561 | - |
| Aureobasidium pullulans | - |
MZKI B802 | - |
| Aureobasidium pullulans MZKI B802 | - |
MZKI B802 | - |
| Debaryomyces hansenii | - |
CBS 767 | - |
| Debaryomyces hansenii CBS 767 | - |
CBS 767 | - |
| Hortaea werneckii | - |
MZKI B736 | - |
| Hortaea werneckii MZKI B736 | - |
MZKI B736 | - |
| Neophaeotheca triangularis | - |
MZKI B741 | - |
| Neophaeotheca triangularis MZKI B741 | - |
MZKI B741 | - |
| Saccharomyces cerevisiae | - |
MZKI K86 | - |
| Saccharomyces cerevisiae MZKI K86 | - |
MZKI K86 | - |
| Trimmatostroma salinum | - |
MZKI B734 | - |
| Trimmatostroma salinum MZKI B734 | - |
MZKI B734 | - |
| Wallemia ichthyophaga | - |
EXF 994 | - |
| Wallemia ichthyophaga EXF 994 | - |
EXF 994 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Saccharomyces cerevisiae | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Aspergillus amstelodami | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Aureobasidium pullulans | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Debaryomyces hansenii | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Hortaea werneckii | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Neophaeotheca triangularis | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Trimmatostroma salinum | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Wallemia ichthyophaga | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Saccharomyces cerevisiae MZKI K86 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Wallemia ichthyophaga EXF 994 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Neophaeotheca triangularis MZKI B741 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Aureobasidium pullulans MZKI B802 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Hortaea werneckii MZKI B736 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Aspergillus amstelodami MZKI A561 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Debaryomyces hansenii CBS 767 | mevalonate + CoA + NADP+ | - |
? | |
| D-3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Trimmatostroma salinum MZKI B734 | mevalonate + CoA + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HMG-CoA reductase | - |
Saccharomyces cerevisiae |
| HMG-CoA reductase | - |
Aspergillus amstelodami |
| HMG-CoA reductase | - |
Aureobasidium pullulans |
| HMG-CoA reductase | - |
Debaryomyces hansenii |
| HMG-CoA reductase | - |
Hortaea werneckii |
| HMG-CoA reductase | - |
Neophaeotheca triangularis |
| HMG-CoA reductase | - |
Trimmatostroma salinum |
| HMG-CoA reductase | - |
Wallemia ichthyophaga |
| HMGR | - |
Saccharomyces cerevisiae |
| HMGR | - |
Aspergillus amstelodami |
| HMGR | - |
Aureobasidium pullulans |
| HMGR | - |
Debaryomyces hansenii |
| HMGR | - |
Hortaea werneckii |
| HMGR | - |
Neophaeotheca triangularis |
| HMGR | - |
Trimmatostroma salinum |
| HMGR | - |
Wallemia ichthyophaga |
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