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Literature summary for 1.1.1.34 extracted from

  • Munoz-Bertomeu, J.; Sales, E.; Ros, R.; Arrillaga, I.; Segura, J.
    Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia (2007), Plant Biotechnol. J., 5, 746-758.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information transgenic expression of the N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase from Arabidopsis thaliana in Lavandula latifolia plants enhances production of essential oils and sterols in the different lines of transgenic plants, expression of HMGR1S also increases the amount of the end-product sterols beta-sitosterol and stigmasterol by 1.8fold and 1.9fold, respectively, but does not affect the accumulation of carotenoids or chlorophylls, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Arabidopsis thaliana 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hydroxymethylglutaryl-CoA + NADPH + H+ Arabidopsis thaliana key enzyme of the mevalonic acid pathway catalysing the first committed step with NADPH as cofactor, overview mevalonate + NADP+ + CoA
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
gene HMG1
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxymethylglutaryl-CoA + NADPH + H+
-
Arabidopsis thaliana mevalonate + NADP+ + CoA
-
?
hydroxymethylglutaryl-CoA + NADPH + H+ key enzyme of the mevalonic acid pathway catalysing the first committed step with NADPH as cofactor, overview Arabidopsis thaliana mevalonate + NADP+ + CoA
-
?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl CoA reductase
-
Arabidopsis thaliana
HMGR1S
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Arabidopsis thaliana