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Literature summary for 1.1.1.34 extracted from

  • Concepcion, J.L.; Gonzalez-Pakanowska, D.; Urbina, J.A.
    3-Hydroxy-3-methylglutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: Subcellular localization and kinetic properties (1998), Arch. Biochem. Biophys., 352, 114-120.
    View publication on PubMed
Search for more literature for 1.1.1.34

Inhibitors

Inhibitors Comment Organism Structure
lovastatin competitive inhibitor for HMG-CoA binding site and noncompetitive inhibitor for NADPH binding site Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 3-hydroxy-3-methylglutaryl-CoA
-
 Trypanosoma cruzi
0.037
-
 NADPH
-
 Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Trypanosoma cruzi 5829
-
glycosome
-
 Trypanosoma cruzi 20015
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Trypanosoma cruzi
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
 Schizotrypanum
-

Purification (Commentary)

Purification (Comment) Organism
-
 Trypanosoma cruzi

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0164
-
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Trypanosoma cruzi (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Trypanosoma cruzi